PHARMACOKINETICS AND EXPOSURE-RESPONSE OF TOFACITINIB IN A PHASE 3 MAINTENANCE STUDY IN ULCERATIVE COLITIS PATIENTS

被引:2
|
作者
Mukherjee, Arnab
D'Haens, Geert R.
Sandborn, William J.
Tsuchiwata, Shinichi
Vong, Camille
Deng, Chenhui
Xie, Rujia
Hazra, Anasuya
Martin, Steven W.
Friedman, Gary
Niezychowski, Wojciech
Su, Chinyu
机构
关键词
D O I
10.1016/S0016-5085(17)32133-9
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Su1917
引用
收藏
页码:S595 / S596
页数:2
相关论文
共 50 条
  • [31] Population Pharmacokinetics and Exposure-Response Modeling Analyses of Golimumab in Children With Moderately to Severely Active Ulcerative Colitis
    Xu, Yan
    Adedokun, Omoniyi J.
    Chan, Daphne
    Hu, Chuanpu
    Xu, Zhenhua
    Strauss, Richard S.
    Hyams, Jeffrey S.
    Turner, Dan
    Zhou, Honghui
    JOURNAL OF CLINICAL PHARMACOLOGY, 2019, 59 (04): : 590 - 604
  • [32] Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis
    Sandborn, William J.
    Su, Chinyu
    Sands, Bruce E.
    D'Haens, Geert R.
    Vermeire, Severine
    Schreiber, Stefan
    Danese, Silvio
    Feagan, Brian G.
    Reinisch, Walter
    Niezychowski, Wojciech
    Friedman, Gary
    Lawendy, Nervin
    Yu, Dahong
    Woodworth, Deborah
    Mukherjee, Arnab
    Zhang, Haiying
    Healey, Paul
    Panes, Julian
    NEW ENGLAND JOURNAL OF MEDICINE, 2017, 376 (18): : 1723 - 1736
  • [33] Tofacitinib Plasma Concentration Monitoring Is Not Needed for Optimization of Induction Therapy in Moderate to Severe Ulcerative Colitis: Results of Pooled Exposure-Response Analyses of Phase 3 Induction Studies
    Mukherjee, Arnab
    Tsuchiwata, Shinichi
    Deng, Chenhui
    Vong, Camille
    Xie, Rujia
    Martin, Steven W.
    Yu, Dahong
    Woodworth, Deborah A.
    Niezychowski, Wojciech
    Su, Chinyu
    GASTROENTEROLOGY, 2016, 150 (04) : S774 - S774
  • [34] Infliximab Exposure-Response Relationship and Thresholds Associated With Endoscopic Healing in Patients With Ulcerative Colitis
    Vande Casteele, Niels
    Jeyarajah, Jenny
    Jairath, Vipul
    Feagan, Brian G.
    Sandborn, William J.
    CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2019, 17 (09) : 1814 - +
  • [35] Exposure-response relationships of etrolizumab in patients with moderately-to-severely active ulcerative colitis
    Kassir, Nastya
    Zhu, Rui
    Moein, Anita
    Langenhorst, Jurgen
    Ribbing, Jakob
    Zhang, Rong
    Tang, Meina T.
    Oh, Young S.
    Zhang, Wenhui
    CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 2022, 11 (09): : 1234 - 1243
  • [36] Exposure-response relationship of vedolizumab subcutaneous treatment in patients with ulcerative colitis: VISIBLE 1
    Rosario, M.
    Polhamus, D.
    Dirks, N.
    Lock, R.
    Yao, X.
    Chen, J.
    Chen, C.
    Sun, W.
    Feagan, B.
    Sandborn, W.
    D'Haens, G.
    JOURNAL OF CROHNS & COLITIS, 2019, 13 : S377 - S378
  • [37] ANALYSIS OF HEMATOLOGICAL CHANGES IN TOFACITINIB-TREATED PATIENTS WITH ULCERATIVE COLITIS ACROSS PHASE 3 INDUCTION AND MAINTENANCE STUDIES
    Lichtenstein, Gary R.
    Moore, Gregory T.
    Soonasra, Arif
    Nduaka, Chudy I.
    Kwok, Kenneth
    Wang, Lisy
    Lawendy, Nervin
    Chan, Gary
    Su, Chinyu
    Loftus, Edward V.
    GASTROENTEROLOGY, 2019, 156 (06) : S1111 - S1111
  • [38] Analysis of haematological changes in tofacitinib-treated patients with ulcerative colitis across Phase 3 induction and maintenance studies
    Lichtenstein, G. R.
    Moore, G. T.
    Soonasra, A.
    Nduaka, C. I.
    Kwok, K.
    Wang, L.
    Lawendy, N.
    Chan, G.
    Su, C.
    Loftus, E. V., Jr.
    JOURNAL OF CROHNS & COLITIS, 2019, 13 : S351 - S352
  • [39] Pharmacokinetics and exposure-response relationships of golimumab in paediatric patients with moderate-to-severe ulcerative colitis: results from a multicentre open-label study
    Adedokun, O. J.
    Chan, D.
    Padgett, L.
    Xu, Y.
    Hyams, J.
    Turner, D.
    Xu, Z.
    Davis, H.
    Strauss, R.
    JOURNAL OF CROHNS & COLITIS, 2016, 10 : S62 - S63
  • [40] Tofacitinib plasma concentration monitoring is not needed for optimisation of induction therapy in moderate-to-severe ulcerative colitis: results of pooled exposure-response analyses of Phase 3 induction studies
    Mukherjee, A.
    Tsuchiwata, S.
    Deng, C.
    Vong, C.
    Xie, R.
    Martin, S. W.
    Yu, D.
    Woodworth, D.
    Niezychowski, W.
    Su, C.
    JOURNAL OF CROHNS & COLITIS, 2016, 10 : S73 - S74