Efficacy of micafungin alone or in combination against systemic murine aspergillosis

被引：72

作者：

Luque, JC

Clemons, KV

Stevens, DA

机构：

[1] Santa Clara Valley Med Ctr, Dept Med, Div Infect Dis, San Jose, CA 95128 USA

[2] Univ Rovira & Virgili, E-43201 Reus, Spain

[3] Calif Inst Med Res, San Jose, CA 95128 USA

[4] Stanford Univ, Dept Med, Div Infect Dis & Geog Med, Stanford, CA 94305 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 04期

关键词：

D O I：

10.1128/AAC.47.4.1452-1455.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We tested the efficacy of micafungin (FK) alone or in combination with other antifungals against systemic murine aspergillosis. FK alone at 10 mg/kg of body weight/dose prolonged survival (P = 0.01) and reduced CFU in the brain and kidney. Combination therapy that used suboptimal FK with amphotericin B or itraconazole prolonged survival. Although no survivors were free of infection, no antagonism was seen. Nikkomycin Z with FK showed significantly greater potency (P < 0.01) than either alone.

引用

页码：1452 / 1455

页数：4

共 50 条

[1] Efficacy of micafungin alone or in combination against experimental pulmonary aspergillosis
Clemons, KV
Stevens, DA
MEDICAL MYCOLOGY, 2006, 44 (01) : 69 - 73
[2] Efficacy of Abelcet and caspofungin, alone or in combination, against CNS aspergillosis in a murine model
Imai, J
Singh, G
Fernandez, B
Clemons, KV
Stevens, DA
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2005, 56 (01) : 166 - 171
[3] Efficacy of Combination Antifungal Therapy with Intraperitoneally Administered Micafungin and Aerosolized Liposomal Amphotericin B against Murine Invasive Pulmonary Aspergillosis
Takazono, Takahiro
Izumikawa, Koichi
Mihara, Tomo
Kosai, Kosuke
Saijo, Tomomi
Imamura, Yoshifumi
Miyazaki, Taiga
Seki, Masafumi
Kakeya, Hiroshi
Yamamoto, Yoshihiro
Yanagihara, Katsunori
Kohno, Shigeru
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (08) : 3508 - 3510
[4] Micafungin alone or in combination with other systemic antifungal therapies in hematopoietic stem cell transplant recipients with invasive aspergillosis
Kontoyiannis, D. P.
Ratanatharathorn, V.
Young, J. -A.
Raymond, J.
Laverdiere, M.
Denning, D. W.
Patterson, T. F.
Facklam, D.
Kovanda, L.
Arnold, L.
Lau, W.
Buell, D.
Marr, K. A.
TRANSPLANT INFECTIOUS DISEASE, 2009, 11 (01) : 89 - 93
[5] Micafungin (FK463), alone or in combination with other systemic antifungal agents, for the treatment of acute invasive aspergillosis
Denning, David W.
Marr, Kieren A.
Lau, Wendi M.
Facklam, David P.
Ratanatharathorn, Voravit
Becker, Cornelia
Ullmann, Andrew J.
Seibel, Nita L.
Flynn, Patricia M.
van Burik, Jo-Anne H.
Buell, Donald N.
Patterson, Thomas F.
JOURNAL OF INFECTION, 2006, 53 (05) : 337 - 349
[6] Combination antifungal therapy of murine aspergillosis: liposomal amphotericin B and micafungin
Graybill, JR
Bocanegra, R
Gonzalez, GM
Najvar, LK
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2003, 52 (04) : 656 - 662
[7] EFFICACY OF CILOFUNGIN ALONE AND IN COMBINATION WITH AMPHOTERICIN-B IN A MURINE MODEL OF DISSEMINATED ASPERGILLOSIS
DENNING, DW
STEVENS, DA
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (07) : 1329 - 1333
[8] Micafungin alone and in combination therapy with deferasirox against Pythium insidiosum
Zanette, R. A.
Jesus, F. P.
Alves, S. H.
Pilotto, M. B.
Weiblen, C.
Santurio, J. M.
MYCOSES, 2012, 55 : 104 - 104
[9] Micafungin alone and in combination therapy with deferasirox against Pythium insidiosum
Zanette, R. A.
Jesus, F. P. K.
Pilotto, M. B.
Weiblen, C.
Poetter, L.
Ferreiro, L.
Alves, S. H.
Santurio, J. M.
JOURNAL DE MYCOLOGIE MEDICALE, 2015, 25 (01): : 91 - 94
[10] EFFICACY OF ORAL SAPERCONAZOLE IN SYSTEMIC MURINE ASPERGILLOSIS
HANSON, LH
CLEMONS, KV
DENNING, DW
STEVENS, DA
JOURNAL OF MEDICAL AND VETERINARY MYCOLOGY, 1995, 33 (05): : 311 - 317

← 1 2 3 4 5 →