Efficacy of Combination Antifungal Therapy with Intraperitoneally Administered Micafungin and Aerosolized Liposomal Amphotericin B against Murine Invasive Pulmonary Aspergillosis

被引：17
|
作者：
Takazono, Takahiro [1 ,2 ]
Izumikawa, Koichi [1 ,2 ]
Mihara, Tomo [1 ,2 ]
Kosai, Kosuke [1 ,2 ]
Saijo, Tomomi [1 ,2 ]
Imamura, Yoshifumi [1 ,2 ]
Miyazaki, Taiga [1 ,2 ]
Seki, Masafumi [1 ,2 ]
Kakeya, Hiroshi [1 ,2 ]
Yamamoto, Yoshihiro [1 ,2 ]
Yanagihara, Katsunori [1 ,2 ,3 ]
Kohno, Shigeru [1 ,2 ]
机构：
[1] Nagasaki Univ, Sch Med, Grad Sch Biomed Sci, Dept Mol Microbiol & Immunol, Nagasaki 8528501, Japan
[2] Nagasaki Univ, Global Ctr Excellence Programs, Nagasaki 8528501, Japan
[3] Nagasaki Univ, Grad Sch Biomed Sci, Dept Lab Med, Nagasaki 8528501, Japan
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 08期
关键词：
MICE;
D O I：
10.1128/AAC.00285-09
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Targeted intrapulmonary delivery of drugs may reduce systemic toxicity and improve treatment efficacy. In the current study, we evaluated the effects of a combination treatment consisting of inhalation of aerosolized liposomal amphotericin B (L-AMB) with intraperitoneal administration of micafungin (MCFG) against murine invasive pulmonary aspergillosis. The combination of aerosolized L-AMB with intraperitoneal MCFG significantly improved the survival rate, and the fungal burdens and histopathology findings after this treatment were superior to those of the control and both monotherapy groups.
引用
收藏
页码：3508 / 3510
页数：3
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