Efficacy of Single-Dose Liposomal Amphotericin B or Micafungin Prophylaxis in a Neutropenic Murine Model of Invasive Pulmonary Aspergillosis

被引：21

作者：

Lewis, Russell E. ^{[1
,2
]}

Albert, Nathaniel D. ^{[1
]}

Kontoyiannis, Dimitrios P. ^{[1
,2
]}

机构：

[1] Univ Houston, Coll Pharm, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 11期

关键词：

D O I：

10.1128/AAC.00715-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In a neutropenic murine model of invasive pulmonary aspergillosis, prophylaxis with single doses of liposomal amphotericin B or micafungin at >= 5 mg/kg of body weight improved animal survival and suppressed the lung fungal burden for up to 7 days after infection, demonstrating the potential utility of infrequent dosing with these antifungals.

引用

页码：4178 / 4180

页数：3

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