Copper-Mediated Aminoazidation, Aminohalogenation, and Aminothiocyanation of β,γ-Unsaturated Hydrazones: Synthesis of Versatile Functionalized Pyrazolines

被引：40

作者：

Wang, Li-Jing ^{[1
,2
]}

Ren, Pei-Xing ^{[1
]}

Qi, Lin ^{[1
]}

Chen, Manman ^{[1
]}

Lu, Yan-Lei ^{[1
]}

Zhao, Jing-Ye ^{[1
]}

Liu, Rui ^{[1
]}

Chen, Jia-Min ^{[1
]}

Li, Wei ^{[1
,2
]}

机构：

[1] Hebei Univ, Coll Chem & Environm Sci, 180 Wusi Donglu, Baoding 071002, Peoples R China

[2] Hebei Univ, Key Lab Med Chem & Mol Diag, Minist Educ, Key Lab Chem Biol Hebei Prov, 180 Wusi Donglu, Baoding 071002, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 15期

基金：

中国国家自然科学基金;

关键词：

ENANTIOSELECTIVE SYNTHESIS; UNACTIVATED ALKENES; CASCADE SYNTHESIS; DIHYDROPYRAZOLES; TETRAHYDROPYRIDAZINES; DIFUNCTIONALIZATION; CYCLOADDITION; ISOXAZOLINES; SUBSTITUENT; DIAMINATION;

D O I：

10.1021/acs.orglett.8b01620

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A versatile method for the rapid synthesis of diverse functionalized pyrazolines has been developed based on copper-mediated aminofunctionalization of beta,gamma-unsaturated hydrazones. The scope of this strategy encompasses a range of difunctionalization reactions: aminoazidation, aminohalogenation, and aminothiocyanation. These reactions provide straightforward access to a series of useful pyrazoline building blocks containing various functional groups that are hard to access traditionally.

引用

页码：4411 / 4415

页数：5

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