Anxiety in Acute Posttraumatic Period is Associated with Reduced Rem-Sleep in Rats

被引：0
|
作者：
Komoltsev, I. G. [1 ]
Levshina, I. P. [1 ]
Novikova, M. R. [1 ]
Tishkina, A. O. [1 ]
Stepanichev, M. Yu. [1 ]
Gulyaeva, N. V. [1 ]
机构：
[1] RAS, Inst Higher Nervous Act & Neurophysiol, Lab Funct Biochem Nervous Syst, Moscow, Russia
来源：
ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA | 2017年 / 67卷 / 02期
关键词：
traumatic brain injury; behavior; EEG; REM-sleep; anxiety; TRAUMATIC BRAIN-INJURY; ELEVATED PLUS-MAZE; EYE-MOVEMENT SLEEP; DEPRESSIVE-DISORDERS; EPILEPSY; DISTURBANCES; WAKEFULNESS; NEUROGENESIS; ILLUMINATION; REDUCTION;
D O I：
10.7868/S0044467717020095
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
To assess early consequences of severe traumatic brain injury (TBI) we used lateral fluid percussion model (3-4 atm) in male Sprague-Dawley rats. To evaluate symptoms of anxiety light-dark box and elevated plus-maze tests were used; to estimate global brain function and sleep disturbances electrocorticogramms (ECoG) were recorded prior TBI and during acute posttraumatic period (first week after injury). Our results suggest that during acute posttraumatic period rats demonstrate symptoms of anxiety associated with reduced percentage of REM-sleep as well as its decreased frequency and amplitude.
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页码：231 / 245
页数：15
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