Preparation of 4,6-disubstituted 5-pyrimidinesulfonamides

被引：0

作者：

Best, WM ^{[1
]}

Fam, MAM ^{[1
]}

Gregory, MJ ^{[1
]}

Kasum, B ^{[1
]}

Keep, PL ^{[1
]}

Lazzaro, S ^{[1
]}

Osner, N ^{[1
]}

Stewart, N ^{[1
]}

Thang, SH ^{[1
]}

Watson, KG ^{[1
]}

机构：

[1] ICI Australia, Res Grp, Ascotvale, Vic 3032, Australia

来源：

SYNTHESIS-STUTTGART | 1998年 / 01期

关键词：

pyrimidine; sulfonamides; trifluoroethoxy; substitution; nucleophilic;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first general synthesis of 4,6-disubstituted 5-pyrimidinesulfonamides is described. Treatment of 4,6-dichloro-5-benzylthiopyrimidine (3) with ethoxide or trifluoroethoxide, oxidation of the benzyithio group to a sulfonyl chloride and reaction with ammonia gave 4,6-dialkoxy-5-pyrimidinesulfonamides 5a,b. Stepwise displacement of the trifluoroethoxy groups in 5a gave a variety of symmetrical and non-symmetrical 4,6-disubstituted 5-pyrimidinesulfonamides 5h-h.

引用

页码：36 / +

页数：4

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