The effect of GABAergic system activity on hyperthermia-induced seizures in rats

被引：11
|
作者：
Fukuda, M [1 ]
Morimoto, T [1 ]
Nagao, H [1 ]
Kida, K [1 ]
机构：
[1] Ehime Univ, Sch Med, Dept Pediat, Shigenobu, Ehime 79102, Japan
来源：
DEVELOPMENTAL BRAIN RESEARCH | 1997年 / 104卷 / 1-2期
关键词：
hyperthermia; GABA; thiosemicarbazide; bicuculine; muscimol; seizure; threshold; duration; adenosine;
D O I：
10.1016/S0165-3806(97)00157-0
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Developing rats were given GABA antagonists and agonist before electrical seizure discharges were induced by heating the brain of a rat with infra-red rays. The thresholds for the GABA antagonist groups were significantly lower than that for the control, and the threshold for the GABA agonist group was significantly higher than that for the control These results support the hypothesis that reduced GABAergic system activity underlies febrile seizures. (C) 1997 Elsevier Science B.V.
引用
收藏
页码：197 / 199
页数：3
相关论文
共 50 条
  • [41] Hyperthermia-induced priming effect in neutrophile granulocytes
    Löer, D
    Elsner, J
    Michalsen, A
    Melchart, D
    Völker, K
    Dobos, G
    FORSCHENDE KOMPLEMENTARMEDIZIN, 1999, 6 (02): : 86 - 88
  • [42] Effect Of Hyperthermia-induced Central Fatigue On Brain Activity During Preparation For Exercise
    Hirai, Minami
    Nakata, Hiroki
    Shibasaki, Manabu
    MEDICINE & SCIENCE IN SPORTS & EXERCISE, 2022, 54 (09) : 246 - 246
  • [43] Hyperthermia-induced changes in the vascular permeability of rats: a model system to examine therapeutic interventions
    Matthew, CB
    DuBose, DA
    Sils, IV
    Tartartini, KA
    JOURNAL OF THERMAL BIOLOGY, 2000, 25 (05) : 381 - 386
  • [44] Effects of levetiracetam on blood-brain barrier disturbances following hyperthermia-induced seizures in rats with cortical dysplasia
    Ahishali, Bulent
    Kaya, Mehmet
    Orhan, Nurcan
    Arican, Nadir
    Ekizoglu, Oguzhan
    Elmas, Imdat
    Kucuk, Mutlu
    Kemikler, Gonul
    Kalayci, Rivaze
    Gurses, Candan
    LIFE SCIENCES, 2010, 87 (19-22) : 609 - 619
  • [45] HYPERTHERMIA-INDUCED EXENCEPHALY IN MICE - EFFECT OF MULTIPLE EXPOSURES
    CHERNOFF, GF
    GOLDEN, JA
    TERATOLOGY, 1988, 37 (01) : 37 - 42
  • [46] Hyperthermia-induced drug targeting
    May, Jonathan P.
    Li, Shyh-Dar
    EXPERT OPINION ON DRUG DELIVERY, 2013, 10 (04) : 511 - 527
  • [47] Hyperthermia-induced myocardial angiogenesis
    Gong, B
    Chen, ZP
    Asimakis, G
    Albrecht, T
    Boor, P
    Motamedi, M
    FASEB JOURNAL, 2002, 16 (04): : A86 - A86
  • [48] Extreme hyperthermia-induced arrhythmogenesis
    Kaur, Tripat
    Sriram, Chenni S.
    Kohli, Utkarsh
    CARDIOLOGY IN THE YOUNG, 2022, 32 (05) : 840 - 843
  • [49] HYPERTHERMIA-INDUCED BRUGADA SYNDROME
    Brown, Jonathan
    Rashid, Hytham
    Pansuriya, Tusharkumar
    Daniel, Michael
    Saunders, Justin T.
    Raza, Syed A.
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2022, 79 (09) : 2470 - 2470
  • [50] Influences of hyperthermia-induced seizures on learning, memory and phosphorylative state of CaMKIIα in rat hippocampus
    Xiong, Yufang
    Zhou, Hui
    Zhang, Lian
    BRAIN RESEARCH, 2014, 1557 : 190 - 200
12345