Fine mapping of the muscular dystrophy (AM) gene on chicken chromosome 2q

被引：3
|
作者：
Yoshizawa, K
Inaba, K
Mannen, H [1 ]
Kikuchi, T
Mizutani, M
Tsuji, S
机构：
[1] Kobe Univ, Fac Agr, Lab Anim Breeding & Genet, Kobe, Hyogo 6578501, Japan
[2] Kobe Univ, Grad Sch Sci & Technol, Nada Ku, Kobe, Hyogo 6578501, Japan
[3] NCNP, Natl Inst Neurosci, Dept Anim Models Human Dis, Tokyo 1828502, Japan
[4] Nippon Inst Biol Sci, Kobuchizawa 4080041, Japan
来源：
ANIMAL GENETICS | 2004年 / 35卷 / 05期
关键词：
chicken; comparative map; linkage map; muscular dystrophy;
D O I：
10.1111/j.1365-2052.2004.01171.x
中图分类号：
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号：
0905 ;
摘要：
Our previous studies revealed that the genetic locus for chicken muscular dystrophy of abnormal muscle (AM) mapped to chromosome 2q, and that the region showed conserved synteny with human chromosome 8q11-24.3. In the current study, we mapped the chicken orthologues of genes from human chromosome 8q11-24 in order to identify the responsible gene. Polymorphisms in the chicken orthologues were identified in the parents of the resource family. Twenty-three genes and expressed sequence tags (ESTs) were mapped to chicken chromosome 2 by linkage analysis. The detailed comparative map shows a high conservation of synteny between chicken chromosome 2q and human chromosome 8q. The AM locus was mapped between [inositol(myo)-1(or4)-monophosphatase 1] (IMPA1) gene and [core-binding factor, runt domain, alpha-subunit 2; translocated to 1; cyclin D-related] (CBFA2T1) gene. The genes located between IMPA1 and CBFA2T1 are the most likely candidates for chicken muscular dystrophy.
引用
收藏
页码：397 / 400
页数：4
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