Swinhoeisterols from the South China Sea Sponge Theonella swinhoei

被引：23

作者：

Li, Jiao ^{[1
]}

Tang, Hua ^{[1
]}

Kurtan, Tibor ^{[2
]}

Mandi, Attila ^{[2
]}

Zhuang, Chun-Lin ^{[1
]}

Su, Li ^{[1
]}

Zheng, Gui-Liang ^{[3
]}

Zhang, Wen ^{[1
]}

机构：

[1] Second Mil Med Univ, Sch Pharm, 325 Guo He Rd, Shanghai 200433, Peoples R China

[2] Univ Debrecen, Dept Organ Chem, POB 400, H-4002 Debrecen, Hungary

[3] Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Otorhinolaryngol Head & Neck Surg, 1665 Kong Jiang Rd, Shanghai 200092, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2018年 / 81卷 / 07期

关键词：

CYCLIC PENTAPEPTIDES; A-C; INHIBITORS; ACETYLTRANSFERASE; P300; 4-METHYLENESTEROLS; CBP/P300;

D O I：

10.1021/acs.jnatprod.8b00281

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Swinhoeisterols C-F (1-4), four new steroids having a rearranged 6/6/5/7 ring system, were isolated from the Xisha sponge Theonella swinhoei, together with the known analogue swinhoeisterol A (5). Their structures were determined based on spectroscopic analysis, TDDFT-ECD and optical rotation calculations, and biogenetic correlations. In an in vitro assay, compound 1 showed an inhibitory effect on (h)p300 with an IC50 value of 8.8 mu M, whereas compounds 2-4 were not active.

引用

页码：1645 / 1650

页数：6

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