Synchronization of skin ablation and microjet injection for an effective transdermal drug delivery

被引：7
|
作者：
Jang, Hun-jae [1 ]
Yeo, Seonggu [1 ]
Yoh, Jack J. [1 ]
机构：
[1] Seoul Natl Univ, Dept Mech & Aerosp Engn, 1 Gwanakro, Seoul 151742, South Korea
来源：
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING | 2016年 / 122卷 / 04期
基金：
新加坡国家研究基金会;
关键词：
Vapor Bubble; Standoff Distance; Porcine Skin; Parabolic Mirror; Bubble Expansion;
D O I：
10.1007/s00339-016-9941-x
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
An Er:YAG laser with 2940-nm wavelength and 150-mu s pulse duration was built for the purpose of combined ablation and microjet injection. A shorter pulse duration compared to common erbium lasers in dentistry is desirable for a synchronization of skin ablation and subsequent microjet injection into target skin for transdermal injection of liquid dose. A single laser beam is split into two for an optimal energy of pre-ablation of skin and the residual energy allocated to a microjet ejection. A newly designed injector consists of an L-shaped chamber and a parabolic mirror in a single unit, and the handheld laser is a part of an integrated system requiring no optical fiber. Through various injection tests using the porcine skin, the effectiveness of the new delivery system is herein evaluated.
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页数：8
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