Efficacy of Kushen decoction (???) on high-fat-diet-induced hyperlipidemia in rats

被引：1

作者：

Mutu, Zhang Jiri ^{[1
,2
]}

Shilong, Liang ^{[1
]}

Peng, Nie ^{[1
]}

Yong'an, Liao ^{[1
]}

Qinying, Ai ^{[1
]}

Xiaojun, Yan ^{[1
]}

Hongning, Liu ^{[1
]}

Yanhua, Ji ^{[1
]}

Zhijun, Zeng ^{[1
]}

机构：

[1] Jiangxi Univ Chinese Med, Res Ctr Different & Dev TCM Basic Theory, Jiangxi Prov Key Lab TCM Etiopathogenisis, Nanchang 330006, Jiangxi, Peoples R China

[2] Inner Mongolia Minzu Uanivers, Mongolian Med Coll, Tongliao 028000, Peoples R China

来源：

JOURNAL OF TRADITIONAL CHINESE MEDICINE | 2022年 / 42卷 / 03期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

liver; hyperlipidemias; RNA-seq; transcriptome; Kushen decoction; SOPHORA-FLAVESCENS; METABOLIC SYNDROME; STATINS; CELL; ADIPOGENESIS; DISEASES; EXTRACT; PATHWAY; OBESITY;

D O I：

10.19852/j.cnki.jtcm.20220225.002

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

OBJECTIVE: To investigate the efficacy and underlying mechanisms of action of Kushen decoction on high-fat-diet-induced hyperlipidemia in rats using RNA-seq technology. METHODS: The efficacy of a Kushen decoction (?????????), at a concentration of 1 mL/g of crude medicine prepared according to the method commonly used in clinical practice, was investigated on 24 specific pathogen-free male Sprague-Dawley rats. Liver tissues were compared using RNA-Seq technology. The differentially expressed genes were further investigated by real-time fluorescent

引用

页码：364 / 371

页数：8

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