Efficacy of Kushen decoction (???) on high-fat-diet-induced hyperlipidemia in rats

被引：1
|
作者：
Mutu, Zhang Jiri [1 ,2 ]
Shilong, Liang [1 ]
Peng, Nie [1 ]
Yong'an, Liao [1 ]
Qinying, Ai [1 ]
Xiaojun, Yan [1 ]
Hongning, Liu [1 ]
Yanhua, Ji [1 ]
Zhijun, Zeng [1 ]
机构：
[1] Jiangxi Univ Chinese Med, Res Ctr Different & Dev TCM Basic Theory, Jiangxi Prov Key Lab TCM Etiopathogenisis, Nanchang 330006, Jiangxi, Peoples R China
[2] Inner Mongolia Minzu Uanivers, Mongolian Med Coll, Tongliao 028000, Peoples R China
来源：
JOURNAL OF TRADITIONAL CHINESE MEDICINE | 2022年 / 42卷 / 03期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
liver; hyperlipidemias; RNA-seq; transcriptome; Kushen decoction; SOPHORA-FLAVESCENS; METABOLIC SYNDROME; STATINS; CELL; ADIPOGENESIS; DISEASES; EXTRACT; PATHWAY; OBESITY;
D O I：
10.19852/j.cnki.jtcm.20220225.002
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
OBJECTIVE: To investigate the efficacy and underlying mechanisms of action of Kushen decoction on high-fat-diet-induced hyperlipidemia in rats using RNA-seq technology. METHODS: The efficacy of a Kushen decoction (?????????), at a concentration of 1 mL/g of crude medicine prepared according to the method commonly used in clinical practice, was investigated on 24 specific pathogen-free male Sprague-Dawley rats. Liver tissues were compared using RNA-Seq technology. The differentially expressed genes were further investigated by real-time fluorescent
引用
收藏
页码：364 / 371
页数：8
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