Generation of integration-free induced pluripotent stem cell lines from four pediatric ADHD patients

被引：6
|
作者：
Grossmann, Leoni [1 ]
Ohki, Cristine Marie Yde [1 ]
Doering, Christian [1 ]
Hoffmann, Per [2 ,3 ,4 ]
Herms, Stefan [2 ,3 ,4 ]
Werling, Anna Maria [1 ]
Walitza, Susanne [1 ,5 ,6 ]
Gruenblatt, Edna [1 ,5 ,6 ,7 ]
机构：
[1] Univ Zurich, Psychiat Univ Hosp Zurich, Dept Child & Adolescent Psychiat & Psychotherapy, Wagist 12, CH-8952 Zurich, Switzerland
[2] Univ Basel, Human Genom Res Grp, Dept Biomed, CH-4031 Basel, Switzerland
[3] Univ Bonn, Inst Human Genet, Sch Med, D-53105 Bonn, Germany
[4] Univ Hosp Bonn, D-53105 Bonn, Germany
[5] Univ Zurich, Neurosci Ctr Zurich, Zurich, Switzerland
[6] Swiss Fed Inst Technol, Zurich, Switzerland
[7] Univ Zurich, Zurich Ctr Integrat Human Physiol, Zurich, Switzerland
来源：
STEM CELL RESEARCH | 2021年 / 53卷
关键词：
D O I：
10.1016/j.scr.2021.102268
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Human induced pluripotent stem cell (iPSC) lines have been derived from four male patients with childhood attention-deficit hyperactivity disorder (ADHD). Children and adolescents between the ages 6 and 18 suffering from ADHD were recruited for this work. Isolated keratinocytes or peripheral blood mononuclear cells from the participants were reprogrammed into iPSCs using non-integrating Sendai virus to deliver the reprogramming factors Oct3/4, Sox2, Klf4 and c-Myc.
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页数：4
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