Discovery of cyclooxygenase inhibitors from medicinal plants used to treat inflammation

被引：102

作者：

Cao, Hongmei ^{[1
]}

Yu, Rui ^{[1
]}

Choi, Yongsoo ^{[1
]}

Ma, Zhong-Ze ^{[2
]}

Zhang, Hongjie ^{[1
]}

Xiang, Wei ^{[1
]}

Lee, David Yue-Wei ^{[2
]}

Berman, Brian M. ^{[3
]}

Moudgil, Kamal D. ^{[4
]}

Fong, Harry H. S. ^{[1
]}

van Breemen, Richard B. ^{[1
]}

机构：

[1] Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Chicago, IL 60680 USA

[2] Harvard Univ, McLean Hosp, Sch Med, Belmont, MA 02178 USA

[3] Univ Maryland, Sch Med, Ctr Integrat Med, James Kernan Hosp Mans, Baltimore, MD 21201 USA

[4] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA

来源：

PHARMACOLOGICAL RESEARCH | 2010年 / 61卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Cyclooxygenase; COX-2; Drug discovery; Botanical dietary supplements; Senkyunolide O; Cryptotanshinone; ULTRAFILTRATION MASS-SPECTROMETRY; PULSED ULTRAFILTRATION; COMBINATORIAL LIBRARIES; BIOLOGICAL EVALUATION; BETULINIC ACID; IDENTIFICATION; CONSTITUENTS;

D O I：

10.1016/j.phrs.2010.02.007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Eleven authenticated botanicals used in the traditional Chinese medicine Huo-Luo-Xiao-Ling Dan were screened for ligands to cyclooxygenase (COX) using pulsed ultrafiltration liquid chromatography-mass spectrometry, and a mass spectrometry-based enzyme assay was used to determine the concentration of each of 17 ligands that inhibited COX-1 or COX-2 by 50% (IC50). Acetyl-11-keto-beta-boswellic acid, beta-boswellic acid, acetyl-alpha-boswellic acid, acetyl-beta-boswellic acid, and betulinic acid were COX-1 selective inhibitors with IC50 values of approximately 10 mu M. Senkyunolide 0 and cryptotanshinone were COX-2 selective inhibitors with IC50 values of 5 mu M and 22 mu M, respectively. Roburic acid and phenethyl-trans-ferulate inhibited COX-1 and COX-2 equally. COX inhibition and the IC50 values of most of these natural product ligands have not been reported previously. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：519 / 524

页数：6

共 50 条

[31] An update on medicinal plants traditionally used to treat diabetes in southeast Sikkim, India
Abhishek Byahut
Arundhati Bag
Proceedings of the Indian National Science Academy, 2022, 88 : 186 - 196
[32] Inhibition of xanthine oxidase by some Chinese medicinal plants used to treat gout
Kong, LD
Cai, Y
Huang, WW
Cheng, CHK
Tan, RX
JOURNAL OF ETHNOPHARMACOLOGY, 2000, 73 (1-2) : 199 - 207
[33] An ethnobotanical study of medicinal plants used to treat skin diseases in northern Pakistan
Khafsa Malik
Mushtaq Ahmad
Muhammad Zafar
Riaz Ullah
Hafiz Majid Mahmood
Bushra Parveen
Neelam Rashid
Shazia Sultana
Syed Nasar Shah
BMC Complementary and Alternative Medicine, 19
[34] An ethnobotanical study of medicinal plants used to treat skin diseases in northern Pakistan
Malik, Khafsa
Ahmad, Mushtaq
Zafar, Muhammad
Ullah, Riaz
Mahmood, Hafiz Majid
Parveen, Bushra
Rashid, Neelam
Sultana, Shazia
Shah, Syed Nasar
Lubna
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2019, 19 (01):
[35] Anti-inflammatory and antioxidant properties of leaf extracts of eleven South African medicinal plants used traditionally to treat inflammation
Ondua, Moise
Njoya, Emmanuel Mfotie
Abdalla, Muna Ali
McGaw, Lyndy J.
JOURNAL OF ETHNOPHARMACOLOGY, 2019, 234 : 27 - 35
[36] Modulation of the enzyme activity of secretory phospholipase A2, lipoxygenase and cyclooxygenase involved in inflammation and disease by extracts from some medicinal plants used for skincare and beauty
Thibane, V. S.
Ndhlala, A. R.
Finnie, J. F.
Van Staden, J.
SOUTH AFRICAN JOURNAL OF BOTANY, 2019, 120 : 198 - 203
[37] Efflux inhibitors from Swazi medicinal plants
Sibandze, G.
Stapleton, P.
Gibbons, S.
PLANTA MEDICA, 2016, 82
[38] α-Glucosidase inhibitors isolated from medicinal plants
Zhenhua Yin
Wei Zhang
Fajin Feng
Yong Zhang
Wenyi Kang
FoodScienceandHumanWellness, 2014, 3(Z1) (Z1) : 136 - 174
[39] Candidate Anti-COVID-19 Medicinal Plants from Ethiopia: A Review of Plants Traditionally Used to Treat Viral Diseases
Tegen, Dires
Dessie, Kindalem
Damtie, Destaw
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2021, 2021
[40] Discovery of Bioactive Compounds from Traditionally used Medicinal Plants: A Profile of Nilufar Z. Mamadalieva
Mamadalieva, Nilufar Z.
EFOOD, 2020, 1 (06) : 410 - 411

← 1 2 3 4 5 →