Synthesis of cyclopropa[c]indeno[1,2-b]quinolines through a MCR/Staudinger/aza-Wittig sequence

被引：6

作者：

Nie, Bing-Jie ^{[1
]}

Wu, Li-Hui ^{[1
]}

Hu, Ruo-Fei ^{[1
]}

Sun, Yang ^{[1
]}

Wu, Jing ^{[1
]}

He, Ping ^{[1
]}

Huang, Nian-Yu ^{[2
]}

机构：

[1] Hubei Univ Arts & Sci, Coll Chem Engn & Food Sci, Xiangyang 441053, Hubei, Peoples R China

[2] China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang, Hubei, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2017年 / 47卷 / 15期

基金：

中国国家自然科学基金;

关键词：

Cyclopropa[c]indeno[1; 2-b]quinolines; multicomponent reaction; spirocyclopropane; Staudinger; aza-Wittig reaction; HIGHLY STEREOSELECTIVE-SYNTHESIS; MULTICOMPONENT REACTIONS; ONE-POT; CYCLOPROPANES; CONSTRUCTION; DERIVATIVES; CHEMISTRY; BIOLOGY; DESIGN; ACIDS;

D O I：

10.1080/00397911.2017.1328065

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Spirocyclopropanes were prepared from aromatic aldehydes, 1,3-indandione and acetophenones through a halogenation/S(N)2-displacement/Michael-initiated ring-closing sequence by a pyridinium-ylide-assisted multicomponent reaction, and their further use was also researched in the construction of cyclopropa[c]indeno[1,2-b]quinolines through subsequent Staudinger/aza-Wittig reactions.

引用

页码：1368 / 1374

页数：7

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