Quality of life, problems, and needs of disease-free breast cancer survivors 5 years after diagnosis

被引:143
|
作者
Schmidt, Martina E. [1 ,2 ]
Wiskemann, Joachim [3 ,4 ]
Steindorf, Karen [1 ,2 ]
机构
[1] Natl Ctr Tumor Dis NCT, Div Phys Act Prevent & Canc, Neuenheimer Feld 581, D-69120 Heidelberg, Germany
[2] German Canc Res Ctr, Neuenheimer Feld 581, D-69120 Heidelberg, Germany
[3] Natl Ctr Tumor Dis NCT, Div Med Oncol, Neuenheimer Feld 460, D-69120 Heidelberg, Germany
[4] Univ Hosp Heidelberg, Neuenheimer Feld 460, D-69120 Heidelberg, Germany
关键词
Breast cancer survivors; Long-term quality of life; Fatigue; Sleep problems; Cognitive function; Menopausal symptoms; INHIBITOR-INDUCED ARTHRALGIA; PRIMARY-CARE PHYSICIANS; LONG-TERM; MENOPAUSAL SYMPTOMS; CARDIORESPIRATORY FITNESS; ADJUVANT THERAPY; FATIGUE; SLEEP; EXERCISE; WOMEN;
D O I
10.1007/s11136-018-1866-8
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
After cancer treatment, it is desirable to maintain or regain a high quality of life (QoL) and the ability to accomplish everyday tasks well. Therefore, we substantiated the scarce knowledge regarding long-term QoL after breast cancer, burdensome problems, and unmet needs for more support. Disease-free breast cancer survivors (n = 190) who had participated in two randomized controlled exercise trials during primary treatment were followed up to 5 years post-diagnosis. QoL-related functions and symptoms (EORTC QLQ-C30/-BR23), health problems, and support needs were assessed. EORTC-QLQ scores were compared with age-matched normative values from the general population in Germany. QoL-related functions and symptoms in patients during cancer treatment were worse compared to healthy references, but largely improved over time. Yet, cognitive function and sleep were still significantly impaired at 5-year follow-up. Other common long-term problems included sexual issues (45% of survivors), hot flashes (38%), pain (34%), fatigue (24%), and polyneuropathy (21%). Regression analyses indicated fatigue having the strongest impact on global QoL. Support needs were expressed mainly for menopausal disorders (43%), physical performance (39%), sleep problems (38%), arthralgia (37%), cognitive problems (36%), weight problems (32%), and fatigue (31%). While QoL in disease-free breast cancer survivors 5 years post-diagnosis was largely comparable to the general population on average, still many survivors suffered from adverse effects. There appears to be a need for ongoing screening and support regarding fatigue, sleep problems, cognitive problems, arthralgia/pain, menopausal/sexual symptoms, physical performance, and weight problems during and several years following breast cancer therapy.
引用
收藏
页码:2077 / 2086
页数:10
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