Regioselective carbon-carbon bond formation in the effector domain of ascomycin

被引：5

作者：

Horvath, A ^{[1
]}

Grassberger, MA ^{[1
]}

Schulz, G ^{[1
]}

Haidl, E ^{[1
]}

Sperner, H ^{[1
]}

Steck, A ^{[1
]}

机构：

[1] Novartis Res Inst, A-1235 Vienna, Austria

来源：

TETRAHEDRON | 2000年 / 56卷 / 38期

关键词：

aldol reaction; enol ether; ketene acetals; regiospecificity; macrocycles;

D O I：

10.1016/S0040-4020(00)00669-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting from 33-O-silyl-protected ascomycin or its 23,24-dehydration product, regio- and stereo-selective formal aldol reactions under carbon-carbon bond formation at C-22, C-23, or C-24 are demonstrated. Additionally, with the 22-silyl enol ether ascomycin derivative a rhodium(I)-catalysed shift of the 19,20 double bond into the 19,38 exocyclic position is observed at elevated temperature. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：7469 / 7476

页数：8

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