Lipoinsulin encapsulated alginate-chitosan capsules: intestinal delivery in diabetic rats

被引：0
|
作者：
Ramadas, M [1 ]
Paul, W
Dileep, KJ
Anitha, Y
Sharma, CP
机构：
[1] Coll Med, Coll Pharmaceut Sci, Thiruvananthapuram 695011, Kerala, India
[2] Sree Chitra Tirunal Inst Med Sci & Technol, Biomed Technol Wing, Biosurface Technol Div, Thiruvananthapuram 695012, Kerala, India
来源：
JOURNAL OF MICROENCAPSULATION | 2000年 / 17卷 / 04期
关键词：
microcapsule; alginate insulin; lipoinsulin; chitosan; diabetes;
D O I：
暂无
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
An oral formulation based on liposome encapsulated alginate-chitosan gel capsules was developed for insulin delivery for the treatment of diabetes. Liposome encapsulation helped to increase the encapsulation efficiency of insulin in alginate-chitosan capsules. This formulation delivers insulin in the neutral environment of the intestine, by-passing the acidic media in the stomach, with increased drug absorption and bioavailability. Oral administration of this formulation was found to reduce blood glucose levels when tested in diabetic rats.
引用
收藏
页码：405 / 411
页数：7
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