What Is the Pathogenic Meaning of Chondrocyte Hypertrophy in Osteoarthritis? Effect of Evc Deletion Through Hedgehog Signaling

被引：0
|
作者：
Lamuedra, Ana [1 ]
Gratal, Paula [1 ]
Luis Ruiz-Perez, Victor [2 ]
Palencia-Campos, Adrian [3 ]
Portal-Nunez, Sergio [4 ]
Herrero-Beaumont, Gabriel [1 ]
Largo, Raquel [1 ]
机构：
[1] IIS Fdn Jimenez Diaz, Madrid, Spain
[2] Inst Invest Biomed Alberto Sols, Madrid, Spain
[3] Adrian Palencia Campos, Madrid, Spain
[4] Univ San Pablo CEU, IMMA, Madrid, Spain
来源：
ARTHRITIS & RHEUMATOLOGY | 2019年 / 71卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
1979
引用
收藏
页数：2
相关论文
共 50 条
  • [31] Human adipose and synovial-derived MSCs synergistically attenuate osteoarthritis by promoting chondrocyte autophagy through FoxO1 signaling
    Wu, Jianqun
    Huang, Songqiang
    Yu, Yangyi
    Lian, Qiang
    Liu, Yang
    Dai, Wenfeng
    Liu, Qisong
    Pan, Yonghao
    Liu, Gui-ang
    Li, Kai
    Liu, Chao
    Li, Guangheng
    STEM CELL RESEARCH & THERAPY, 2024, 15 (01)
  • [32] Liquiritin reduces chondrocyte apoptosis through P53/PUMA signaling pathway to alleviate osteoarthritis (vol 343, 122536, 2024)
    Qiu, Min
    Cheng, Liangyan
    Xu, Jianbo
    Jin, Minwei
    Yuan, Wenhua
    Ge, Qinwen
    Zou, Kaiao
    Chen, Jiali
    Huang, Yuliang
    Li, Ju
    Zhu, Liming
    Xu, Bing
    Zhang, Chunchun
    Jin, Hongting
    Wang, Pinger
    LIFE SCIENCES, 2024, 350
  • [33] Picroside II suppresses chondrocyte pyroptosis through MAPK/NF-κB/NLRP3 signaling pathway alleviates osteoarthritis
    Wang, Fanchen
    Xiao, Jiacong
    Li, Miao
    He, Qi
    Wang, Xintian
    Pan, Zhaofeng
    Li, Shaocong
    Wang, Haibin
    Zhou, Chi
    PLOS ONE, 2024, 19 (08):
  • [34] WISP-1 induced by mechanical stress contributes to fibrosis and hypertrophy of the ligamentum flavum through Hedgehog-Gli1 signaling
    Chao Sun
    Qinghong Ma
    Jian Yin
    Han Zhang
    Xinhui Liu
    Experimental & Molecular Medicine, 2021, 53 : 1068 - 1079
  • [35] MicroRNA-130a regulates chondrocyte proliferation and alleviates osteoarthritis through PTEN/PI3K/Akt signaling pathway
    Zhang, Yun
    Xu, Shaochen
    Huang, Eric
    Zhou, Haichao
    Li, Bing
    Shao, Chenni
    Yang, Yunfeng
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2018, 41 (06) : 3699 - 3708
  • [36] Hedgehog signaling activates Cbfa1 gene expression in chondrocytes through a responsive region in the promoter identified by deletion analysis.
    Takamoto, M
    Tsuji, K
    Yamashita, T
    Nifuji, A
    Komori, T
    Noda, M
    JOURNAL OF BONE AND MINERAL RESEARCH, 2000, 15 : S145 - S145
  • [37] Cordycepin inhibits chondrocyte hypertrophy of mesenchymal stem cells through PI3K/Bapx1 and Notch signaling pathway
    Cao, Zhen
    Dou, Ce
    Li, Jianmei
    Tang, Xiangyu
    Xiang, Junyu
    Zhao, Chunrong
    Zhu, Lingyu
    Bai, Yun
    Xiang, Qiang
    Dong, Shiwu
    BMB REPORTS, 2016, 49 (10) : 548 - 553
  • [38] Epigenetic regulation of chondrocyte hypertrophy and apoptosis through Sirt1/P53/P21 pathway in surgery-induced osteoarthritis
    Xu, Mao
    Feng, Meng
    Peng, Hang
    Qian, Zhuang
    Zhao, Liting
    Wu, Shufang
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020, 528 (01) : 179 - 185
  • [39] RIP1 inhibition reduces chondrocyte apoptosis through downregulating nuclear factor-kappa B signaling in a mouse osteoarthritis model
    Zhao, Hong
    Wang, Chenzhong
    Liu, Bo
    Weng, Ziyu
    Shi, Yi
    Zhang, Chi
    MOLECULAR BIOLOGY REPORTS, 2024, 51 (01)
  • [40] Lycopodium japonicum Thunb. inhibits chondrocyte apoptosis, senescence and inflammation in osteoarthritis through STING/NF-κB κ B signaling pathway
    Ma, Jiawei
    Zhang, Hanwen
    Wang, Ze
    Xu, Cong
    Tan, Hongye
    Sun, Yun
    Zheng, Rukang
    Jin, Zebin
    Li, Yuanyuan
    Ge, Xinjiang
    Wu, Yaosen
    Zhou, Yifei
    JOURNAL OF ETHNOPHARMACOLOGY, 2024, 335
12345