GLYCEMIC VARIABILITY IN TYPE 2 DIABETIC PATIENTS WITH CHRONIC KIDNEY DISEASE

Glycaemic variability is an independent determinant of vascular complications in diabetes mellitus. The aim of our study was to asses glycemic variability in patients with CKD and type 2 diabetes mellitus(T2DM), using a continuous glucose monitoring system. We selected subjects with T2DM and CKD stages 3 and 4. Collected data was: anthropometric measurement, actual antidiabetic treatment, the duration of diabetes, HbA1c in the last 3 months, creatinine level. The coefficient of variation of blood glucose(CV) and the mean amplitude of glucose excursion (MAGE) were determined. We divided the data base in 3 parts, according to the creatinine tertiles 1,73 and 2,235 respectively. The middle group was excluded. No correlations was found between HbA1, BMI, duration of diabetes and glycaemic variability indices. The correlations between CV and eGFR, in both groups, seem to be sufficiently strong (r=0,38 and r=0,59 respectively) to warrant further investigation on a larger set of patients.