Altered cortical functional network during behavioral inhibition in individuals with childhood trauma

被引:9
|
作者
Kim, Sungkean [1 ,2 ]
Kim, Ji Sun [3 ]
Shim, Miseon [4 ]
Im, Chang-Hwan [2 ]
Lee, Seung-Hwan [1 ,5 ]
机构
[1] Inje Univ, Clin Emot & Cognit Res Lab, Goyang, South Korea
[2] Hanyang Univ, Dept Biomed Engn, Seoul, South Korea
[3] Soonchunhyang Univ, Cheonan Hosp, Dept Psychiat, Cheonan, South Korea
[4] Univ Missouri Kansas City, Dept Psychiat, Kansas City, MO USA
[5] Inje Univ, Ilsan Paik Hosp, Dept Psychiat, Goyang, South Korea
来源
SCIENTIFIC REPORTS | 2018年 / 8卷
基金
新加坡国家研究基金会;
关键词
SEVERE INSTITUTIONAL DEPRIVATION; EARLY-LIFE STRESS; BRAIN STRUCTURE; SEXUAL-ABUSE; ADVERSE EXPERIENCES; RESPONSE-INHIBITION; COGNITIVE CONTROL; NEURAL-NETWORK; GO/NOGO TASK; EEG;
D O I
10.1038/s41598-018-28329-6
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Individuals who have prior history of childhood traumatic experiences are at a high risk for a variety of psychological and behavioral problems throughout their lifetime. This study aimed to investigate whether such individuals exhibit altered cortical functional networks during a behavioral inhibition task. One hundred fifty-three non-clinical individuals were recruited and instructed to perform a Go/NoGo task during an electroencephalograph. Source-level weighted functional networks based on the graph theory were analyzed for NoGo-P3 processing. Based on their total scores on the childhood trauma questionnaire (CTQ) participants were divided into three groups: low CTQ, middle CTQ, and high CTQ. Results at the global level indicated decreased strength, clustering coefficient, and efficiency for the low and gamma bands in the high CTQ group. In addition, the path length of the low beta band was observed to be longer in the high CTQ group than the low CTQ group. At the nodal level, the nodal clustering coefficient of high CTQ group was decreased in left primary somatosensory cortex and middle occipital gyrus for the low beta band, and in left superior temporal gyrus for the gamma band. The nodal clustering coefficient of the left primary somatosensory cortex showed a significant negative correlation with the total CTQ score for the low beta band. In addition, the nodal clustering coefficient of the left middle occipital gyrus for the low beta band and superior temporal gyrus for the gamma band showed significant negative correlations with the emotional neglect score. Our results demonstrate an altered cortical functional network in individuals who experienced childhood trauma. In particular, the left primary somatosensory cortex, middle occipital gyrus, and superior temporal gyrus were found to be vulnerable in individuals who experienced childhood trauma, especially emotional neglect.
引用
收藏
页数:10
相关论文
共 50 条
  • [41] Altered static and dynamic functional network connectivity related to cognitive decline in individuals with white matter hyperintensities
    Chen, Haifeng
    Xu, Jingxian
    Lv, Weiping
    Xu, Yun
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2023, 455
  • [42] IBS Patients Show Altered Behavioral and Functional Brain Responses During an Orienting Attention Task
    Hubbard, Catherine S.
    Mayer, Emeran A.
    Hong, Jui-Yang
    Ebrat, Bahar
    Smith, Suzanne R.
    Heendeniya, Nuwanthi
    Tillisch, Kirsten
    Labus, Jennifer S.
    Naliboff, Bruce D.
    GASTROENTEROLOGY, 2012, 142 (05) : S547 - S547
  • [43] Early Childhood Behavioral Inhibition Predicts Altered Social and Emotional Functioning in Early Adulthood: An Ecological Momentary Assessment Study
    Hawes, Mariah T.
    Olino, Thomas M.
    Klein, Daniel N.
    EMOTION, 2024,
  • [44] Graph Theory Analysis of the Cortical Functional Network During Sleep in Patients With Depression
    Song, Yingjie
    Wang, Kejie
    Wei, Yu
    Zhu, Yongpeng
    Wen, Jinfeng
    Luo, Yuxi
    FRONTIERS IN PHYSIOLOGY, 2022, 13
  • [45] Altered functional network activities for behavioral adjustments and Bayesian learning in young men with Internet gaming disorder
    MA, SHAN-SHAN
    LI, R. CHIANG-SHAN
    Zhang, Sheng
    Worhunsky, D. Patrick
    Zhou, Nan
    ZHANG, JIN-TAO
    Liu, Lu
    Yao, Yuan-Wei
    FANG, XIAO-YI
    JOURNAL OF BEHAVIORAL ADDICTIONS, 2021, 10 (01) : 112 - 122
  • [46] Functional Abnormality of the Executive Control Network in Individuals With Obesity During Delay Discounting
    Zhang, Wenchao
    Li, Guanya
    Manza, Peter
    Hu, Yang
    Wang, Jia
    Lv, Ganggang
    He, Yang
    von Deneen, Karen M.
    Yu, Juan
    Han, Yu
    Cui, Guangbin
    Volkow, Nora D.
    Nie, Yongzhan
    Ji, Gang
    Wang, Gene-Jack
    Zhang, Yi
    CEREBRAL CORTEX, 2022, 32 (09) : 2013 - 2021
  • [47] Altered dynamic functional connectivity of nucleus accumbens subregions in major depressive disorder: the interactive effect of childhood trauma and diagnosis
    Zou, Yurong
    Yu, Tong
    Zhu, Liwen
    Xu, Qing
    Li, Yuhong
    Chen, Juran
    Luo, Qianyi
    Peng, Hongjun
    SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE, 2024, 19 (01)
  • [48] Pre-diabetes is associated with altered functional connectivity density in cortical regions of the default-mode network
    Lopez-Vilaret, Karel M. M.
    Fernandez-Alvarez, Marina
    Shokri-Kojori, Ehsan
    Tomasi, Dardo
    Cantero, Jose L. L.
    Atienza, Mercedes
    FRONTIERS IN AGING NEUROSCIENCE, 2022, 14
  • [49] Impact of childhood trauma on the abnormal functional connectivity of brain regions in the fear network model of panic disorder
    Hong, Ang
    Zhou, Shuangyi
    Yang, Chen
    Liu, Xitong
    Su, Shanshan
    Wang, Zhen
    JOURNAL OF AFFECTIVE DISORDERS, 2023, 329 : 500 - 510
  • [50] Does cortical brain morphology act as a mediator between childhood trauma and transition to psychosis in young individuals at ultra-high risk?
    Rapado-Castro, Marta
    Whittle, Sarah
    Pantelis, Christos
    Thompson, Andrew
    Nelson, Barnaby
    Ganella, Eleni P.
    Lin, Ashleigh
    Reniers, Renate L. E. P.
    McGorry, Patrick D.
    Yung, Alison R.
    Wood, Stephen J.
    Bartholomeusz, Cali F.
    SCHIZOPHRENIA RESEARCH, 2020, 224 : 116 - 125