Glp-1/gdf15 dual agonist to treat obesity and hyperglycaemia in mice and non-human primates

被引:0
|
作者
Zhang, Y. Y. [1 ]
Kharitonenkov, A. [1 ]
Zhao, X. Y. [1 ]
Dong, X. N. [1 ]
Zhang, Y. Y. [1 ]
Zou, H. X. [1 ]
Jin, Y. G. [1 ]
Guo, W. [1 ]
Zhai, P. [1 ]
Chen, X. [1 ]
机构
[1] Beijing QL Biopharmaceut Co Ltd, Beijing, Peoples R China
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
198
引用
收藏
页码:S103 / S104
页数:2
相关论文
共 50 条
  • [21] Combined therapy of mesenchymal stem cells with a GLP-1 receptor agonist, liraglutide, on an inflammatory-mediated diabetic non-human primate model
    Navabi, Roghayeh
    Negahdari, Babak
    Hajizadeh-Saffar, Ensiyeh
    Hajinasrollah, Mostafa
    Jenab, Yaser
    Rabbani, Shahram
    Pakzad, Mohamad
    Hassani, Seyedeh-Nafiseh
    Hezavehei, Maryam
    Jafari-Atrabi, Mohammad
    Tahamtani, Yaser
    Baharvand, Hossein
    LIFE SCIENCES, 2021, 276
  • [22] Efficacy of CT-996, an Oral Small Molecule GLP-1 Receptor Agonist, in Human GLP-1 Receptor Knockin Mice and Obese Cynomolgus Monkeys
    Luo, Jian
    Rodriguez, Ruben
    Hergarden, Anne
    Tracy, Ted
    Lam, Davina
    Garai, Sumanta
    Marshall, Dan
    Hansen, Stig K.
    Chakravarthy, Manu
    DIABETES, 2024, 73
  • [23] Cotadutide (GLP-1/Glucagon dual receptor agonist) modulates hypothalamic orexigenic and anorexigenic neuropeptides in obese mice
    Spezani, Renata
    Marinho, Thatiany Souza
    Reis, Thiago Santos
    Aguila, Marcia Barbosa
    Mandarim-de-Lacerda, Carlos A.
    PEPTIDES, 2024, 173
  • [24] Pharmacological characterisation of MED10382, a glucagon/GLP-1 dual agonist for treatment of obesity and type 2 diabetes
    Rossi, A.
    Naylor, J.
    Will, S.
    Bhagroo, N.
    Bednarek, M. A.
    Coghlan, M. P.
    Konkar, A.
    Hornigold, D. C.
    DIABETOLOGIA, 2016, 59 : S58 - S58
  • [25] GLP-1 Receptor Agonist Exenatide Attenuates the Detrimental Effects of Obesity on Inflammatory Profile in Testis and Sperm Quality in Mice
    Zhang, Erhong
    Xu, Fen
    Liang, Hua
    Yan, Jinhua
    Xu, Haixia
    Li, Zhuo
    Wen, Xingqiao
    Weng, Jianping
    AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2015, 74 (05) : 457 - 466
  • [26] An oral GLP-1 and GIP dual receptor agonist improves metabolic disorders in high fat-fed mice
    Ma, Teng
    Lu, Weisheng
    Wang, Yongkang
    Qian, Peng
    Tian, Hong
    Gao, Xiangdong
    Yao, Wenbing
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2022, 914
  • [27] MEDI0382, a GLP-1/glucagon receptor dual agonist, improves NASH and reduces liver fibrosis in mice
    Trevaskis, J. L.
    Boland, M. L.
    Conway, J.
    Guionaud, S.
    Grimsby, J.
    Jermutus, L.
    Rhodes, C. J.
    DIABETOLOGIA, 2018, 61 : S590 - S590
  • [28] Alcohol intake in non-human primates and alcohol cue-induced brain activation in alcohol use disorder patients: Effects of GLP-1 receptor agonists
    Fink-Jensen, A.
    Klausen, M. K.
    Jensen, M. E.
    ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH, 2023, 47 : 66 - 66
  • [29] Cholecystokinin-1 receptor agonist induced pathological findings in the exocrine pancreas of non-human primates
    Nyborg, Niels Chresten Berg
    Kirk, Rikke Kaae
    de Boer, Anne Sietske
    Andersen, David Wederkinck
    Bugge, Anne
    Wulff, Birgitte Schjellerup
    Thorup, Inger
    Clausen, Trine Ryberg
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2020, 399
  • [30] Engineering a potent and long-acting GLP-1/Y2 receptor dual agonist as a multi-agonist therapy for diabetes and obesity
    Xu, Jing
    Wang, Shuang
    Wu, Han
    Chen, De
    Han, Jing
    Lin, Qisi
    PEPTIDES, 2023, 169