Exosomes: potential for early detection in pancreatic cancer

被引：32

作者：

Lu, Lingeng ^{[1
]}

Risch, Harvey A. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Yale Sch Publ Hlth, Dept Chron Dis Epidemiol,Yale Canc Ctr, 333 Cedar St, New Haven, CT 06520 USA

来源：

FUTURE ONCOLOGY | 2016年 / 12卷 / 08期

关键词：

biomarkers; early detection; exosomes; pancreatic cancer; CELL-DERIVED EXOSOMES; DIABETES-MELLITUS; DENDRITIC CELLS; MICRORNA; BIOMARKERS; MICROVESICLES; EXPRESSION; DIAGNOSIS; GLYPICAN-1; PROTEIN;

D O I：

10.2217/fon-2015-0005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Progress in the treatment of patients with pancreatic cancer at earlier stages has motivated research in identifying novel noninvasive or minimally invasive biomarkers for early detection. Exosomes, which contain bioactive molecules (such as proteins, RNAs and lipids), are membrane-structured nanovesicles that are secreted from living cells and are found in human body fluids. As functional mediators, exosomes play key roles in cell-cell communications, regulating diverse biological processes. Here we aim to examine recent findings in the potential diagnostic value of serum exosomes in pancreatic cancer.

引用

页码：1081 / 1090

页数：10

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