Size-controlled synthesis, characterization, and cytotoxicity study of monodisperse poly(dimethylsiloxane) nanoparticles

被引:15
|
作者
Baipaywad, Phornsawat [1 ]
Kim, Yunkyung [1 ]
Wi, Jung-Sub [2 ]
Paik, Taejong [1 ]
Park, Hansoo [1 ]
机构
[1] Chung Ang Univ, Sch Integrat Engn, Seoul 156756, South Korea
[2] Korea Res Inst Stand & Sci, Ctr Nanobio Measurement, Daejeon, South Korea
基金
新加坡国家研究基金会;
关键词
Poly(dimethylsiloxane); Nanoparticles; Colloidal; Surface modification; Biomaterials; SILICA NANOPARTICLES; MESOPOROUS ORGANOSILICA; POLYDIMETHYLSILOXANE; HYBRIDIZATION; TOXICITY; DELIVERY; GROWTH;
D O I
10.1016/j.jiec.2017.04.023
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Polydimethylsiloxane (PDMS) nanoparticles (NPs) were synthesized using dimethylsiloxane and tetraethyl orthosilicate as precursors via a modified Stober process. A diluted ammonia solution was added to the reaction mixture. This induced base-catalyzed hydrolysis and condensation, forming dispersed nanocolloids. The as -synthesized organosilica NPs exhibited excellent colloidal stability without any noticeable precipitation in water. The particle size was readily tunable, in a diameter range of approximately 50-300 nm, by changing the amount of catalysts added to the reaction. Furthermore, we evaluated the cytotoxicity of PDMS NPs using a CCK-8 assay to demonstrate that PDMS NPs are promising for biomedical applications. (C) 2017 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:177 / 182
页数:6
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