Planar-Chiral Thioureas as Hydrogen-Bond Catalysts

被引：59
|
作者：
Schneider, Jakob F. [1 ]
Falk, Florian C. [1 ]
Froehlich, Roland [2 ]
Paradies, Jan [1 ]
机构：
[1] Karlsruhe Inst Technol, D-76131 Karlsruhe, Germany
[2] Univ Munster, D-48149 Munster, Germany
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 2010卷 / 12期
关键词：
Thioureas; Hydrogen bonds; Cyclophanes; Organocatalysis; Chirality; ASYMMETRIC CATALYSIS; MACRO RINGS; LIGANDS; CARBENE; ORGANOCATALYSIS; DERIVATIVES; COMPLEXES; ACID;
D O I：
10.1002/ejoc.200901353
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of the first enantiopure planar-chiral thiourea catalysts is herewith described. New catalysts 1-3 were applied in asymmetric transformations, such as the Friedel-Crafts alkylation of indole, as well as in the transfer hydrogenation of nitroolefins. Bifunctional catalysts 2 and 3 exhibit enhanced activity in the investigated reactions, demonstrating their potential for organic synthesis.
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页码：2265 / 2269
页数：5
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