New insight into coronary endothelial dysfunction: Role of endothelin

被引：17
|
作者：
Cannan, CR [1 ]
Mathew, V [1 ]
Lerman, A [1 ]
机构：
[1] Mayo Clin & Mayo Fdn, Div Cardiovasc Dis & Internal Med, Rochester, MN 55905 USA
来源：
JOURNAL OF LABORATORY AND CLINICAL MEDICINE | 1998年 / 131卷 / 04期
关键词：
D O I：
10.1016/S0022-2143(98)90179-2
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
The coronary endothelium plays a central role in the modulation of coronary vascular tone via the production and release of vasoactive mediators. A number of cardiovascular disease states are associated with coronary endothelial dysfunction, which results in an imbalance between vasoactive substances, Endothelin is a potent vasoconstrictor produced by the coronary endothelium and has been implicated in the pathogenesis of coronary endothelial dysfunction, This review examines the relationship between endothelin and coronary endothelial dysfunction as it occurs in a number of cardiovascular disease states and explores potential therapeutic options.
引用
收藏
页码：300 / 305
页数：6
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