Novel Pyrazole-Hydrazone Derivatives Containing an Isoxazole Moiety: Design, Synthesis, and Antiviral Activity

被引：55
|
作者：
Yang, Zaibo [1 ]
Li, Pei [2 ]
Gan, Xiuhai [3 ]
机构：
[1] Qiannan Normal Univ Nationalities, Sch Chem & Chem Engn, Duyun 558000, Guizhou, Peoples R China
[2] Kaili Univ, Qiandongnan Engn & Technol Res Ctr Comprehens Uti, Kaili 556011, Guizhou, Peoples R China
[3] Guizhou Normal Coll, Coll Chem & Life Sci, Guiyang 550018, Guizhou, Peoples R China
来源：
MOLECULES | 2018年 / 23卷 / 07期
基金：
中国国家自然科学基金;
关键词：
pyrazole-hydrazone; isoxazole; antiviral activity; tobacco mosaic virus; INSECTICIDAL ACTIVITIES; ACYLHYDRAZONE DERIVATIVES; ANTIBACTERIAL ACTIVITY; BIOLOGICAL EVALUATION; ANTIFUNGAL ACTIVITY; OXIME;
D O I：
10.3390/molecules23071798
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this study, a series of novel pyrazole-hydrazone derivatives containing an isoxazole moiety were synthesized. Antiviral bioassays indicated that some of the title compounds exhibited better in vivo antiviral activities against tobacco mosaic virus (TMV). In particular, compounds 6a, 6c and 6q exhibited the best curative activity, protection activity, and inactivation activity against TMV, respectively, which were superior to those of Ningnanmycin. This study demonstrated that this series of novel pyrazole-hydrazone derivatives containing an isoxazole amide moiety could effectively control TMV.
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页数：12
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