Eurysterols A and B, cytotoxic and antifungal steroidal sulfates from a marine sponge of the genus Euryspongia

被引：26
|
作者：
Boonlarppradab, Chollaratt [1 ]
Faulkner, D. John [1 ]
机构：
[1] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Bio,ed, La Jolla, CA 92093 USA
来源：
JOURNAL OF NATURAL PRODUCTS | 2007年 / 70卷 / 05期
关键词：
D O I：
10.1021/np060472c
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new steroidal sulfates, eurysterols A (1) and B (2), were isolated from an undescribed marine sponge of the genus Euryspongia collected in Palau. The structures of the new compounds were assigned by NMR spectroscopic data interpretation. Compounds 1 and 2 showed cytotoxicity against human colon carcinoma (HCT-116) cells with IC50 values of 2.9 and 14.3 mu g/mL, respectively, and exhibited antifungal activity against amphotericin B-resistant and wild-type strains of Candida albicans with MIC values, in turn, of 15.6 and 62.5 mu g/mL.
引用
收藏
页码：846 / 848
页数：3
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