Anti-inflammatory effect of extract of Terminalia sericea roots in an experimental model of colitis

被引：9
|
作者：
Mochizuki, Miyako [1 ]
Hasegawa, Noboru [1 ]
机构：
[1] Gifu Womens Univ, Fac Home Econ, Dept Hlth & Nutr, Gifu 5012592, Japan
来源：
JOURNAL OF HEALTH SCIENCE | 2007年 / 53卷 / 03期
关键词：
inflammatoy bowel disease; Terminalia sericea; sericoside; 2,4,6-trinitorobenzene sulfonic acid; myeloperoxidase;
D O I：
10.1248/jhs.53.329
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Sericoside is a traditional herbal saponin from Terminalia sericea (Family: Combretaceae). We studied the anti-inflammatory effect of sericoside on acute inflammatory colitis induced by ethanolic 2,4,6-trinitrobenzene sulfonic acid in male rats. Intestinal mucosa lesions were judged by their macroscopic damage score and measuring by myeloperoxidase (MPO) activity. Pretreatment of sericoside (30 mg/kg daily by gavage for 10 days) significantly reduced the macroscopic damage score and inhibited MPO activity. These results showed that sericoside attenuated the inflammatory effect and suggested its possible role in treating acute inflammatory diseases such as inflammatory bowel disease.
引用
收藏
页码：329 / 331
页数：3
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