Real-Time Magnetic Resonance Imaging-Guided Focal Laser Therapy in Patients with Low-Risk Prostate Cancer

被引：101
|
作者：
Raz, Orit [1 ,2 ]
Haider, Masoom A. [2 ,3 ]
Davidson, Sean R. H. [2 ,4 ]
Lindner, Uri [2 ]
Hlasny, Eugen [2 ,3 ]
Weersink, Robert [2 ,4 ]
Gertner, Mark R. [2 ,4 ]
Kucharcyzk, Walter [2 ,3 ]
McCluskey, Stuart A. [2 ,5 ]
Trachtenberg, John [1 ,2 ]
机构：
[1] Princess Margaret Hosp, Div Urol, Dept Surg Oncol, Univ Hlth Network, Toronto, ON M5G 2M9, Canada
[2] Univ Toronto, Toronto, ON, Canada
[3] Princess Margaret Hosp, Dept Med Imaging, Univ Hlth Network, Toronto, ON M5G 2M9, Canada
[4] Princess Margaret Hosp, Ontario Canc Inst, Univ Hlth Network, Biophys & Bioimaging Div, Toronto, ON M5G 2M9, Canada
[5] Princess Margaret Hosp, Dept Anesthesia & Pain Management, Univ Hlth Network, Toronto, ON M5G 2M9, Canada
来源：
EUROPEAN UROLOGY | 2010年 / 58卷 / 01期
关键词：
Prostate neoplasm; Magnetic resonance imaging; Focal therapy; CRYOSURGERY;
D O I：
10.1016/j.eururo.2010.03.006
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Two patients with low-risk prostate cancer (PCa) were treated with outpatient in-bore magnetic resonance imaging (MRI)-guided focal laser ablation. The tumor was identified on MRI. A laser fiber was delivered via a catheter inserted through a perineal template and guided to the target with MRI. The tissue temperature was monitored during laser ablation by MRI thermometry. Accumulated thermal damage was calculated in real time. Immediate post-treatment contrast-enhanced MRI confirmed devascularization of the target. No adverse events were noted. MRI-guided focal laser therapy of low-risk PCa is feasible and may offer a good balance between cancer control and side effects. (C) 2010 European Association of Urology. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：173 / 177
页数：5
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