Occupational Factors and Risk of Parkinson's Disease: A Population-Based Case-Control Study

被引：81

作者：

Firestone, Jordan A. ^{[1
,2
,3
]}

Lundin, Jessica I. ^{[3
]}

Powers, Karen M. ^{[3
]}

Smith-Weller, Terri ^{[3
]}

Franklin, Gary M. ^{[1
,3
]}

Swanson, Phillip D. ^{[1
]}

Longstreth, W. T., Jr. ^{[1
,4
]}

Checkoway, Harvey ^{[3
,4
]}

机构：

[1] Univ Washington, Dept Neurol, Seattle, WA 98104 USA

[2] Univ Washington, Dept Med, Seattle, WA 98104 USA

[3] Univ Washington, Dept Environm & Occupat Hlth Sci, Seattle, WA 98104 USA

[4] Univ Washington, Dept Epidemiol, Seattle, WA 98104 USA

来源：

AMERICAN JOURNAL OF INDUSTRIAL MEDICINE | 2010年 / 53卷 / 03期

基金：

美国国家卫生研究院;

关键词：

risk factors in epidemiology; Parkinson's disease/parkinsonism; toxicology; occupational; human; MOVEMENT-DISORDERS; PESTICIDE EXPOSURE; MANGANESE; INFLAMMATION; DIAGNOSIS; COHORT; LEAD;

D O I：

10.1002/ajim.20788

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background Parkinson's disease (PD) has been associated with various workplace factors, but the evidence is inconsistent. Objective To estimate the risk of PD associated with various jobs and work-place exposures. Methods We conducted a population-based, case-control study of 404 incident PD cases and 526 age and sex-matched controls, collecting self-reported work histories including job titles and exposures to various industrial toxicants. Relative risks of PD from these exposures were estimated with odds ratios (OR) and 95% confidence intervals (CI) using logistic regression. Results Risk was not significantly affected by farming work, by metal work, or by exposure to pesticides, metals, or solvents. Conclusions: These findings do not provide support for the hypothesis that workplace factors affect the risk of PD. Am. J. Ind. Med. 53:217-223, 2010. (C) 2009 Wiley-Liss, Inc.

引用

页码：217 / 223

页数：7

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