Effect of antiretroviral therapy on cardiac risk markers in people living with HIV/AIDS

被引:1
|
作者
Gupta, Pulin Kumar [1 ]
Tyagi, Saurabh [1 ]
Sheoran, Ankita [1 ]
Jain, Princi [1 ]
Koner, Sai Kiran [1 ]
Sharma, Lokesh Kumar [2 ]
Singh, Saurabh Kumar [1 ]
Khura, Jayanti [1 ]
机构
[1] Dr Ram Manohar Lohia Hosp, Atal Bihari Vajpayee Inst Med Sci, Dept Med, New Delhi, India
[2] Dr Ram Manohar Lohia Hosp, Atal Bihari Vajpayee Inst Med Sci, Dept Biochem, New Delhi, India
关键词
Antiretroviral therapy; carotid intimal medial thickness; HIV; high-sensitivity C reactive protein; INTIMA-MEDIA THICKNESS; CARDIOVASCULAR-DISEASE; HIV; IMMUNODEFICIENCY; ASSOCIATION; ACTIVATION;
D O I
10.4103/ijstd.ijstd_72_21
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Introduction: Chronic HIV infection and antiretroviral therapy (ART) are the major causes of cardiovascular diseases (CVDs) and mortality in HIV patients. This study was conducted to look upon the effect of ART on CVD risk markers in patients on different ART regimens and ART-naive patients. Methods: It was a cross-sectional, observational study done on 120 HIV-infected patients. CV risk markers were assessed and correlated with disease-specific factors within individual subgroups differentiated as Group A (ART naive), Group B (first-line ART), and Group C (second-line ART). Carotid intimal medial thickness (CIMT) and high-sensitivity C reactive protein (hsCRP) were done to classify cases as having CVD. Results: CVD risk parameters were found to be significantly higher in cases on ART, as compared to ART-naive cases. The mean CIMT among cases in Group C, Group B, and Group A was 0.072 +/- 0.01 cm, 0.063 +/- 0.01 cm, and 0.055 +/- 0.01 cm, respectively (P < 0.01). 95%, 65% and 25% cases in Group C, Group B, and Group A, respectively, had high CIMT (> 0.06 cm) and were seen to be directly correlated with disease-related factors, i.e., duration of disease and ART, type of ART, and low CD4 cell counts. hsCRP was significantly increased in 65 out of total 120 cases. The mean hsCRP in Group A, Group B, and Group C was 3.69 +/- 3.37, 4.21 +/- 3.4, and 5.72 +/- 3.54 mg/L, respectively (P < 0.01), which corresponds to the high risk of CVD. Conclusion: CVD risk parameters of CIMT and hsCRP are seen to be higher in patients on ART than ART-naive subjects.
引用
收藏
页码:52 / 55
页数:4
相关论文
共 50 条
  • [41] Quality of Life of People Living with HIV/AIDS Initiating Antiretroviral Therapy in the Single Tablet Regimen Era
    Costa, Juliana O.
    Ceccato, Maria das Gracas B.
    Almeida-Brasil, Celline C.
    Perdigao, Romara E. A.
    Silveira, Micheline R.
    Bonolo, Palmira F.
    Acurcio, Francisco A.
    PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 2017, 26 : 152 - 153
  • [42] DEVELOPMENT AND EXTERNAL VALIDATION OF A PROGNOSTIC MODEL FOR SURVIVAL OF PEOPLE LIVING WITH HIV/AIDS INITIATING ANTIRETROVIRAL THERAPY
    Wang, J.
    Yuan, T.
    Ding, H.
    Xu, J.
    Keusters, W.
    Ling, X.
    Fu, L.
    Zhu, Q.
    Li, Q.
    Tang, X.
    Cai, W.
    Hong, H.
    Li, L.
    Zou, H.
    SEXUALLY TRANSMITTED INFECTIONS, 2021, 97 : A150 - A151
  • [43] AN OVERVIEW OF ANTIRETROVIRAL THERAPY ON PEOPLE LIVING WITH HIV/AIDS IN MANOKWARI, FAKFAK AND SORONG CITY, WEST PAPUA
    Adiningsih, Setyo
    Purba, Dedi Ananta
    Natalia, Evi Iriani
    Wike, Irawati
    Fitriana, Eva
    Widiyanti, Mirna
    Hutapea, Hotma Martogi L.
    BULETIN PENELITIAN KESEHATAN, 2021, 49 (01): : 21 - 28
  • [44] Increases In Physical Activity Improves HDL Cholesterol In People Living With HIV/AIDS Taking Antiretroviral Therapy
    Miller, Camerra C.
    Estill, Olivia
    Hand, Gregory A.
    Jaggers, Jason R.
    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2017, 49 (05): : 79 - 80
  • [45] Predictors of adherence to antiretroviral therapy among people living with HIV and AIDS at the regional hospital of Sokode, Togo
    Yaya, Issifou
    Landoh, Dadja Essoya
    Saka, Bayaki
    Patchali, P'Niwe Massoubayo
    Wasswa, Peter
    Aboubakari, Abdoul-Samadou
    N'Dri, Mathias Kouame
    Patassi, Akouda Akessiwe
    Kombate, Koussake
    Pitche, Palokinam
    BMC PUBLIC HEALTH, 2014, 14
  • [46] Development and external validation of a prognostic model for survival of people living with HIV/AIDS initiating antiretroviral therapy
    Wang, Junfeng
    Yuan, Tanwei
    Ding, Haibo
    Xu, Junjie
    Keusters, Willem R.
    Ling, Xuemei
    Fu, Leiwen
    Zhu, Qiyu
    Li, Quanmin
    Tang, Xiaoping
    Cai, Weiping
    Shang, Hong
    Li, Linghua
    Zou, Huachun
    LANCET REGIONAL HEALTH-WESTERN PACIFIC, 2021, 16
  • [47] Occurrence of opportunistic infections in people living with HIV/AIDS following antiretroviral therapy in West Bengal, India
    Chakraborty, S.
    Rahman, M.
    Saha, B.
    IMMUNOLOGY, 2011, 135 : 145 - 145
  • [48] Fears about antiretroviral therapy among users of the internet forum for people living with HIV/AIDS in Russia
    Dudina, Victoria I.
    Judina, Darja I.
    King, Elizabeth J.
    AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV, 2017, 29 (02): : 268 - 270
  • [49] Virologic success under antiretroviral therapy among people living with HIV/AIDS in the state of Parana, Brazil
    Dias, Frederico Alves
    Hofelmann, Doroteia Aparecida
    Rattmann, Yanna Dantas
    EINSTEIN-SAO PAULO, 2021, 19 : eAO5800
  • [50] Predictors of adherence to antiretroviral therapy among people living with HIV and AIDS at the regional hospital of Sokodé, Togo
    Issifou Yaya
    Dadja Essoya Landoh
    Bayaki Saka
    P’Niwè Massoubayo Patchali
    Peter Wasswa
    Abdoul-samadou Aboubakari
    Mathias Kouamé N’Dri
    Akouda Akessiwe Patassi
    Koussake Kombaté
    Palokinam Pitche
    BMC Public Health, 14