DNA damage and oxidative stress in long-lived aquatic organisms

被引：16

作者：

Wojtczyk-Miaskowska, A. ^{[1
]}

Schlichtholz, B. ^{[1
]}

机构：

[1] Med Univ Gdansk, Dept Biochem, Debinki 1, PL-80211 Gdansk, Poland

来源：

DNA REPAIR | 2018年 / 69卷

关键词：

DNA repair pathways; Longevity; ROS; Oxidative stress; FOXO; TRACHEMYS-SCRIPTA-ELEGANS; URCHIN STRONGYLOCENTROTUS-PURPURATUS; FORKHEAD TRANSCRIPTION FACTOR; SHARK SOMNIOSUS-MICROCEPHALUS; QUAHOG ARCTICA-ISLANDICA; ANOXIA-TOLERANT TURTLE; BASE EXCISION-REPAIR; EXTENDS LIFE-SPAN; SEA-URCHIN; REACTIVE OXYGEN;

D O I：

10.1016/j.dnarep.2018.07.003

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The maintenance of genomic integrity through the DNA repair processes is essential for proper cellular metabolism, growth, and development. DNA damage plays a key role in mutagenesis and the development of cancer. The cellular DNA damage response activates complex signaling pathways that may promote not only DNA repair and survival but also can trigger cell suicide. Exceptionally long-lived animals may allow explaining the mechanisms of healthy aging without cancer. One of the particular emphases of this review is the link between oxidative stress, DNA repair pathways, and longevity. We specifically focus on the long-lived aquatic organisms, which provide a novel understanding of both healthspan and lifespan despite high oxidative stress caused by environmental factors.

引用

页码：14 / 23

页数：10

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