5-Amino-Substituted Derivatives of 4-Nitrofurazane: Synthesis, Structure, and Biological Activity

被引：1
|
作者：
Galkina, I. V. [1 ]
Takhautdinova, G. L. [1 ]
Ivshin, K. A. [1 ]
Khayarov, Kh. R. [1 ]
Islamov, D. R. [1 ]
Bakhtiyarova, Yu. V. [1 ]
Yamalieva, L. N. [1 ]
Kataeva, O. N. [1 ]
Galkin, V. I. [1 ]
机构：
[1] Kazan Volga Reg Fed Univ, Ul Kremlevskaya 18, Kazan 420008, Tatarstan, Russia
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2018年 / 88卷 / 05期
关键词：
substituted anilines; 5-chloro-4-nitrobenzofurazane; nucleophilic aromatic substitution; heterocyclic compounds; 4-NITROBENZOFURAZANS; TRIPHENYLPHOSPHINE;
D O I：
10.1134/S1070363218050092
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
New amination reactions of 5-chloro-4-nitrobenzofurazane with different amines were studied. The reactions of 5-chloro-4-nitrobenzofurazane with 2,4,6-trichloro-, para-acetyl-, and para-carboxyethylanilines gave the products of aromatic nucleophilic substitution of the chlorine substituent in the nitrogenous heterocycle, the composition and structure of which was established by chemical, physical, and physicochemical methods and X-ray diffraction analysis. The thermal stability was studied by synchronous thermogravimetry and differential scanning calorimetry (TGaEuro'DSC). The synthesized compounds showed a high antibacterial and antimycotic activity against human and animal pathogenic microflora.
引用
收藏
页码：898 / 902
页数：5
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