Factors associated with human herpesvirus type 8 infection in an injecting drug user cohort

Background: Human herpesvirus type 8 (HHV-8) has been infrequently studied in injecting drug user (IDU) populations. Goal: To estimate the seroprevalence of HHV-8 and risk factors for infection in a cohort of 2946 IDUs. Study Design: In this nested cross-sectional study of 390 IDUs, lytic HHV-8 indirect immunofluorescence assay (IFA) was utilized to estimate the HHV-8 seroprevalence. Multivariate logistic regression was used to assess risk factors for infection. Results: The HHV-8 seroprevalence among the IDUs examined in 1988 was 11.5% (95% confidence interval, 8.5-15.13). HHV-8 seroprevalence in this population was associated with being female (OR = 2.2; P = 0.080), having a larger body mass index (OR = 3.0; P = 0.053), and history of genital warts (OR = 4.0; P = 0.023). Injection of any drug more than daily exhibited an inverse effect on HHV-8 seropositivity (OR = 0.5; P = 0.085). Conclusion: The seroprevalence of HHV-8 in this population is similar to that seen in the general population, with risk factors being more consistent with sexual behaviors than injection drug use.