Biophysical investigations of complement receptor 2 (CR2, CD21) ligand interactions reveal specific amino acid contacts unique to each receptor-ligand pair

被引:0
|
作者
Kovacs, James M. [1 ]
Eisenmesser, Elan Z. [2 ]
Hannan, Jonathan P. [3 ]
Holers, V. Michael [1 ]
机构
[1] Univ Colorado, Div Rheumatol, Sch Med, Aurora, CO USA
[2] Univ Colorado, Dept Biochem, Sch Med, Aurora, CO USA
[3] Univ Edinburgh, Inst Struct & Mol Biol, Sch Biol Sci, Edinburgh EH8 9YL, Midlothian, Scotland
关键词
D O I
10.1016/j.molimm.2010.05.190
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
262
引用
收藏
页码:2261 / 2261
页数:1
相关论文
共 50 条
  • [21] Ligation of the functional domain of complement receptor type 2 (CR2, CD21) is relevant for complex formation in T cell lines
    Prodinger, WM
    Larcher, C
    Schwendinger, M
    Dierich, MP
    JOURNAL OF IMMUNOLOGY, 1996, 156 (07): : 2580 - 2584
  • [22] Co-ligation of the B cell receptor with complement receptor 2 (CR2/CD21) using its natural ligand C3dg: Activation without engagement of an inhibitory signaling pathway
    Lyubchenko, T
    Dal Porto, J
    Cambier, J
    Holers, M
    FASEB JOURNAL, 2005, 19 (04): : A951 - A951
  • [23] B cell expression of the complement receptor 2 (CR2/CD21) constitutes a novel biomarker for COVID-19 severity
    Marcos-Jimenez, Ana
    Delgado-Wick, Pablo
    Diaz-Fernandez, Paula
    Montes, Nuria
    Fernandez-Lazaro, Iris
    Andreu-Martinez, Rosa M.
    Lopez, Noelia
    Cuesta-Mateos, Carlos
    Munoz-Calleja, Cecilia
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2024, 54 : 1680 - 1680
  • [24] Human complement receptor 2 (CR2/CD21) as a receptor for DNA: Implications for its roles in the immune response and the pathogenesis of systemic lupus erythematosus (SLE)
    Asokan, Rengasamy
    Banda, Nirmal K.
    Szakonyi, Gerda
    Chen, Xiaojiang S.
    Holers, V. Michael
    MOLECULAR IMMUNOLOGY, 2013, 53 (1-2) : 99 - 110
  • [25] An intronic silencer regulates B lymphocyte cell and stage specific expression of the human complement receptor type 2 (CR2,CD21) gene.
    Makar, KW
    Pham, CT
    Dehoff, M
    OConnor, S
    Jacobi, S
    Holers, VM
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1997, 99 (01) : 980 - 980
  • [26] The structural basis for complement receptor type 2 (CR2, CD21)-mediated alternative pathway activation of complement: studies with CR2 deletion mutants and vaccinia virus complement-control protein-CR2 chimeras
    Johnson, AA
    Rosengard, AM
    Skjodt, K
    Ahearn, JM
    Leslie, RGQ
    EUROPEAN JOURNAL OF IMMUNOLOGY, 1999, 29 (12) : 3837 - 3844
  • [27] Human complement receptor (CR2/CD21) is a receptor for DNA: implications for its roles in the immune response and the pathogenesis of systemic lupus erythematosus (SLE)
    Asokan, R
    Lyubchenko, T
    Szakonyi, G
    Hannan, JP
    Kotzin, BL
    Chen, XS
    Holers, VM
    MOLECULAR IMMUNOLOGY, 2004, 41 (2-3) : 205 - 205
  • [28] Human complement receptor (CR2/CD21) is a receptor for DNA: Implications for its roles in the immune response and the pathogenesis of systemic lupus erythematosus (SLE)
    Asokan, R
    Lyubchenko, T
    Szakonyi, G
    Aramowizc, K
    Boackle, S
    Chen, XJ
    Holers, VM
    FASEB JOURNAL, 2005, 19 (04): : A886 - A886
  • [29] An intronic silencer regulates B lymphocyte cell- and stage-specific expression of the human complement receptor type 2 (CR2, CD21) gene
    Makar, KW
    Pham, CTN
    Dehoff, MH
    O'Connor, SM
    Jacobi, SM
    Holers, VM
    JOURNAL OF IMMUNOLOGY, 1998, 160 (03): : 1268 - 1278
  • [30] ANALYSIS OF EPITOPE EXPRESSION AND THE FUNCTIONAL REPERTOIRE OF RECOMBINANT COMPLEMENT RECEPTOR-2 (CR2/CD21) IN MOUSE AND HUMAN-CELLS
    CAREL, JC
    FRAZIER, B
    LEY, TJ
    HOLERS, VM
    JOURNAL OF IMMUNOLOGY, 1989, 143 (03): : 923 - 930