Amphiphilic α-helical antimicrobial peptides and their structure/function relationships

被引：157
|
作者：
Dennison, SR
Wallace, J
Harris, F
Phoenix, DA [1 ]
机构：
[1] Univ Cent Lancashire, Fac Sci, Deans Off, Preston PR1 2HE, Lancs, England
[2] Univ Cent Lancashire, Dept Forens & Investigat Sci, Preston PR1 2HE, Lancs, England
[3] Univ Cent Lancashire, Dept Phys Math & Astron, Preston PR1 2HE, Lancs, England
来源：
PROTEIN AND PEPTIDE LETTERS | 2005年 / 12卷 / 01期
关键词：
D O I：
10.2174/0929866053406084
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
To facilitate microbial membrane invasion, amphiphilic alpha-helical antimicrobial peptides (alpha-AMPs) show a spatial segregation of hydrophobic and hydrophilic residues about the alpha-helical long axis. Here we discuss potential mechanisms by which these peptides are able to disrupt membrane structure and the structural characteristics, which are required for function.
引用
收藏
页码：31 / 39
页数：9
相关论文
共 50 条
  • [41] APOLAR HELICAL PEPTIDES MIMICKING AMPHIPHILIC HELICES BY HYDRATION OF BACKBONE - CRYSTAL-STRUCTURE RESULTS
    KARLE, IL
    FLIPPENANDERSON, JL
    UMA, K
    BALARAM, P
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1987, 35 (04) : 371 - 371
  • [42] Exploring structure/function relationships of bacterial lipopolysaccharides and lipid A with man-made surfaces presenting antimicrobial peptides
    Uzarski, Joshua R.
    Mello, Charlene M.
    Hittle, Lauren E.
    Ernst, Robert K.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 248
  • [43] High Resolution Structures and Structure-Function Relationships in Histidine-Rich Antimicrobial Peptides from Cod
    McDonald, Mark
    Mannion, Michael
    Pike, Damien
    Lewis, Krystina
    Browne, Mitchell
    Rise, Matthew L.
    Booth, Valerie
    BIOPHYSICAL JOURNAL, 2013, 104 (02) : 600A - 600A
  • [44] Application of 'HESH' Descriptors for the Structure-Activity Relationships of Antimicrobial Peptides
    Shu, Mao
    Jiang, Yongjun
    Yang, Li
    Wu, Yuqian
    Mei, Hu
    Li, Zhiliang
    PROTEIN AND PEPTIDE LETTERS, 2009, 16 (02): : 143 - 149
  • [45] Investigating sequence, structure and function relationships in antimicrobial peptoids
    Bolt, H.
    Woodhouse, V.
    Ichinose, W.
    Williams, E.
    Cobb, S.
    Bromley, E.
    EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2017, 46 : S299 - S299
  • [46] Use of parallel synthesis to probe structure-activity relationships among 12-helical β-peptides:: Evidence of a limit on antimicrobial activity
    Porter, EA
    Weisblum, B
    Gellman, SH
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (32) : 11516 - 11529
  • [47] Structure-Activity Relationships in Two Antimicrobial Peptides Based on Chemokine Helical Segments: RP-1 and IL-8α
    Bourbigot, Sarah
    Booth, Valerie
    BIOPHYSICAL JOURNAL, 2009, 96 (03) : 409A - 410A
  • [48] Antifungal activity of designed α-helical antimicrobial peptides
    Xu, Ruicheng
    Tang, Jing
    Hadianamrei, Roja
    Liu, Suyu
    Lv, Songwei
    You, Rongrong
    Pan, Fang
    Zhang, Peng
    Wang, Nan
    Cai, Zhiqiang
    Zhao, Xiubo
    BIOMATERIALS SCIENCE, 2023, 11 (08) : 2845 - 2859
  • [49] Structures, function and applications of amphiphilic peptides
    Santoso, SS
    Vauthey, S
    Zhang, SG
    CURRENT OPINION IN COLLOID & INTERFACE SCIENCE, 2002, 7 (5-6) : 262 - 266
  • [50] Photocrosslinking of RNA and PhotoMet-Containing Amphiphilic α-Helical Peptides
    Hyun, Soonsil
    Han, Areum
    Yu, Jaehoon
    CHEMBIOCHEM, 2009, 10 (06) : 987 - 989
12345