A possible replication of avian influenza viruses in human monocytic cells

Human monocytic cells newly established from healthy male donor grown in vitro were infected with influenza viruses originated from poultry, swine, and humans. All of three strains of avian influenza viruses examined were able to replicate in the cells in showing clear CPE. The infectivity of progeny viruses was ranged 10 (2.75-3.00) TCID50 per ml when the cells were infected with ca. m.o.i. 1. Each of two virus strains originated form swine and humans were abortive in the cells, even though some CPE appeared. This is suggesting a possibility that avian influenza viruses examined have potentiality to infect and to replicate in human monocytes.