Daratumumab (Anti-CD38) for Treatment of Disseminated Nontuberculous Mycobacteria in a Patient With Anti-Interferon-γ Autoantibodies

被引：30
|
作者：
Ochoa, Sebastian [1 ]
Ding, Li [1 ]
Kreuzburg, Samantha [1 ]
Treat, Jennifer [2 ]
Holland, Steven M. [1 ]
Zerbe, Christa S. [1 ]
机构：
[1] NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, Bethesda, MD 20892 USA
[2] Med Sci & Comp, Rockville, MD USA
来源：
CLINICAL INFECTIOUS DISEASES | 2021年 / 72卷 / 12期
基金：
美国国家卫生研究院;
关键词：
daratumumab; mycobacteria; disseminated; interferon gamma; autoantibodies;
D O I：
10.1093/cid/ciaa1086
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Patients with autoantibodies to interferon-gamma (IFN-gamma) may develop severe nontuberculous mycobacterial infections. We describe the novel use of daratumumab in a patient with autoantibodies to IFN-gamma who had progressive infection, resulting in clinical and radiographic improvement.
引用
收藏
页码：2206 / 2208
页数：3
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