In Vitro Activity of Eravacycline in Combination with Colistin Against OXA-type Carbapenemase Producing Klebsiella pneumoniae Isolates

被引：2
|
作者：
Ozger, H. Selcuk [1 ]
Cuhadar, Tugba [2 ]
Yildiz, Serap Suzuk [3 ,4 ]
Gulmez, Zehra Demirbas [1 ]
Tunccan, Ozlem Guzel [1 ]
Kalkanci, Ayse [2 ]
Simsek, Husniye [3 ]
Bakkaloglu, Zekiye [4 ]
Dizbay, Murat [1 ]
机构：
[1] Gazi Univ, Dept Infect Dis & Clin Microbiol, Sch Med, TR-06560 Ankara, Turkey
[2] Gazi Univ, Dept Clin Microbiol, Sch Med, Ankara, Turkey
[3] Minist Hlth, Gen Directorate Publ Hlth, Natl AMR Surveillance Lab, Ankara, Turkey
[4] Minist Gen Directorate Publ Hlth, Cent Lab, Ankara, Turkey
来源：
GAZI MEDICAL JOURNAL | 2021年 / 32卷 / 2A期
关键词：
Eravacycline; Colistin; Synergy; Klebsiella pneumoniae; Time-kill assay; RESISTANT ENTEROBACTERIACEAE; ACINETOBACTER-BAUMANNII; SYNERGY; FLUOROCYCLINE; SURVEILLANCE; TIGECYCLINE; EFFICACY; GENES; VIVO;
D O I：
10.12996/gmj.2021.64
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective: The synergistic activity of eravacycline in combination with colistin on Oxacillinase (OXA) producing carbapenem-resistant Klebsiella pneumoniae isolates (CR-Kp) was evaluated in this study. Methods: Minimum inhibitory concentrations of meropenem were determined by the broth microdilution method. All strains screened for carbapenemase activity by PCR. Chequerboard assay and time-kill analysis were used to assess potential synergy. Results: Synergistic activity was found in 40 % of the strains by chequerboard assay. No antagonism was detected. Comparing to colistin alone at subinhibitory concentrations synergistic and bactericidal activity was observed when it combined with eravacycline. A Similar activity was also observed in colistinresistant CR- Kp isolates. Conclusion: Our results indicate that Eravacycline and colistin combination may be a potential therapeutic option for the treatment of CR- Kp infections.
引用
收藏
页码：276 / 280
页数：5
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