Synthesis of some fused heterocycles based on thieno[2,3-b]pyridine and their antimicrobial activity

被引：5
|
作者：
El-Essawy, F. A. [1 ]
Hawatta, M. A. [1 ]
Abdel-Megied, A. E. -S. [1 ]
El-Sherbeny, D. A. [1 ]
机构：
[1] Fac Sci, Dept Chem, Shibin Al Kawm, Egypt
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2010年 / 46卷 / 03期
关键词：
imidazole; pyridothienopyrimidine; 1,2,3,4-tetrazoles; 1,2,4-triazoles; antibacterial; antifungal activity; cyclocondensation;
D O I：
10.1007/s10593-010-0508-z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reaction of 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carbonitrile with ethylenediamine in the presence of a catalytic amount of carbon disulfide afforded 2-(4,5-dihydro-1H-imidazol-2-yl)-4,6-dimethylthieno-[2,3-b]pyridine-3-amine while its reaction with triethyl orthoformate followed by the reaction with hydrazine hydrate gave 4-imino-7,9-dimethylpyrido[3',2':4,5]thieno[3,2-d]pyrimidine-3(4H)-amine. These two derivatives underwent cyclocondensation reactions with commercially available reactants to afford new heterocycles containing the thieno[2,3-b]pyridine moiety. Some of the synthesized derivatives were tested for antimicrobial and antifungal activity.
引用
收藏
页码：325 / 333
页数：9
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