Inhibition of Lats1/p-YAP1 pathway mitigates neuronal apoptosis and neurological deficits in a rat model of traumatic brain injury

被引：17

作者：

Li, Di ^{[1
,2
]}

Ji, Jia-Xuan ^{[3
]}

Xu, Yi-Tian ^{[4
]}

Ni, Hai-Bo ^{[1
]}

Rui, Qin ^{[5
]}

Liu, Hui-Xiang ^{[1
]}

Jiang, Feng ^{[1
]}

Gao, Rong ^{[1
]}

Chen, Gang ^{[6
]}

机构：

[1] Soochow Univ, Peoples Hosp Zhangjiagang 1, Dept Neurosurg, Suzhou, Peoples R China

[2] Soochow Univ, Peoples Hosp Zhangjiagang 1, Translat Med Ctr, Suzhou, Peoples R China

[3] Nanjing Univ Chinese Med, Zhangjiagang Hosp Tradit Chinese Med, Dept Neurosurg, Suzhou, Peoples R China

[4] Nanjing Med Univ, Sch Basic Med Sci, Nanjing, Jiangsu, Peoples R China

[5] Soochow Univ, Peoples Hosp Zhangjiagang 1, Clin Lab, Suzhou, Peoples R China

[6] Soochow Univ, Affiliated Hosp 1, Dept Neurosurg, Suzhou, Peoples R China

来源：

CNS NEUROSCIENCE & THERAPEUTICS | 2018年 / 24卷 / 10期

关键词：

Lats1; neurological deficit; neuronal apoptosis; traumatic brain injury; YAP1; ORGAN SIZE CONTROL; HIPPO PATHWAY; CELL-PROLIFERATION; STROMAL CELLS; TBI; HEMORRHAGE; SECONDARY; RECOVERY; SURVIVAL; GROWTH;

D O I：

10.1111/cns.12833

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

AimsTo investigate the roles of Lats1/p-YAP1 pathway in TBI-induced neuronal apoptosis and neurological deficits in rats. ResultsWe found that Lats1 and YAP1 were expressed in cerebral cortex neurons of Sprague-Dawley rats, and the phosphorylation levels of Lats1 and YAP1 in injured regions were significantly increased after TBI. Furthermore, inhibition of Lats1 not only decreased the level of p-YAP1, but also attenuated neuronal apoptosis and neurological impairment. ConclusionsOur work demonstrates that inhibition of Lats1/p-YAP1 pathway mitigates neuronal apoptosis and neurological deficits in a rat model of TBI.

引用

页码：906 / 916

页数：11

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