Inhibition of Lats1/p-YAP1 pathway mitigates neuronal apoptosis and neurological deficits in a rat model of traumatic brain injury

被引：17
|
作者：
Li, Di [1 ,2 ]
Ji, Jia-Xuan [3 ]
Xu, Yi-Tian [4 ]
Ni, Hai-Bo [1 ]
Rui, Qin [5 ]
Liu, Hui-Xiang [1 ]
Jiang, Feng [1 ]
Gao, Rong [1 ]
Chen, Gang [6 ]
机构：
[1] Soochow Univ, Peoples Hosp Zhangjiagang 1, Dept Neurosurg, Suzhou, Peoples R China
[2] Soochow Univ, Peoples Hosp Zhangjiagang 1, Translat Med Ctr, Suzhou, Peoples R China
[3] Nanjing Univ Chinese Med, Zhangjiagang Hosp Tradit Chinese Med, Dept Neurosurg, Suzhou, Peoples R China
[4] Nanjing Med Univ, Sch Basic Med Sci, Nanjing, Jiangsu, Peoples R China
[5] Soochow Univ, Peoples Hosp Zhangjiagang 1, Clin Lab, Suzhou, Peoples R China
[6] Soochow Univ, Affiliated Hosp 1, Dept Neurosurg, Suzhou, Peoples R China
来源：
CNS NEUROSCIENCE & THERAPEUTICS | 2018年 / 24卷 / 10期
关键词：
Lats1; neurological deficit; neuronal apoptosis; traumatic brain injury; YAP1; ORGAN SIZE CONTROL; HIPPO PATHWAY; CELL-PROLIFERATION; STROMAL CELLS; TBI; HEMORRHAGE; SECONDARY; RECOVERY; SURVIVAL; GROWTH;
D O I：
10.1111/cns.12833
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
AimsTo investigate the roles of Lats1/p-YAP1 pathway in TBI-induced neuronal apoptosis and neurological deficits in rats. ResultsWe found that Lats1 and YAP1 were expressed in cerebral cortex neurons of Sprague-Dawley rats, and the phosphorylation levels of Lats1 and YAP1 in injured regions were significantly increased after TBI. Furthermore, inhibition of Lats1 not only decreased the level of p-YAP1, but also attenuated neuronal apoptosis and neurological impairment. ConclusionsOur work demonstrates that inhibition of Lats1/p-YAP1 pathway mitigates neuronal apoptosis and neurological deficits in a rat model of TBI.
引用
收藏
页码：906 / 916
页数：11
相关论文
共 50 条
  • [1] Inhibition of Epac2 Attenuates Neural Cell Apoptosis and Improves Neurological Deficits in a Rat Model of Traumatic Brain Injury
    Zhang, Ling
    Zhang, Li
    Liu, Huixiang
    Jiang, Feng
    Wang, Huanjing
    Li, Di
    Gao, Rong
    FRONTIERS IN NEUROSCIENCE, 2018, 12
  • [2] PARP-1 Inhibition Attenuates Neuronal Loss, Microglia Activation and Neurological Deficits after Traumatic Brain Injury
    Stoica, Bogdan A.
    Loane, David J.
    Zhao, Zaorui
    Kabadi, Shruti V.
    Hanscom, Marie
    Byrnes, Kimberly R.
    Faden, Alan I.
    JOURNAL OF NEUROTRAUMA, 2014, 31 (08) : 758 - 772
  • [3] Involvement of YAP and LATS1 in lung development in a rat model of nitrofen-induced congenital diaphragmatic hernia
    Liao, Junzuo
    Liu, Wenying
    Zhang, Libin
    Li, Qin
    Hou, Fang
    TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2020, 19 (03) : 541 - 547
  • [4] Inhibition of the p-SPAK/p-NKCC1 signaling pathway protects the blood-brain barrier and reduces neuronal apoptosis in a rat model of surgical brain injury
    Gong, Yating
    Wu, Muyao
    Gao, Fan
    Shi, Mengying
    Gu, Haiping
    Gao, Rong
    Dang, Bao-Qi
    Chen, Gang
    MOLECULAR MEDICINE REPORTS, 2021, 24 (04)
  • [5] Deletion of Mst1 attenuates neuronal loss and improves neurological impairment in a rat model of traumatic brain injury
    Li, Di
    Ni, Haibo
    Rui, Qin
    Gao, Rong
    Chen, Gang
    BRAIN RESEARCH, 2018, 1688 : 15 - 21
  • [6] Nitroxides affect neurological deficits and lesion size induced by a rat model of traumatic brain injury
    Zakarya, Razia
    Sapkota, Arjun
    Chan, Yik Lung
    Shah, Jadvi
    Saad, Sonia
    Bottle, Steven E.
    Oliver, Brian G.
    Gorrie, Catherine A.
    Chen, Hui
    NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2020, 97 : 57 - 65
  • [7] Hyperbaric oxygen effects on neuronal apoptosis associations in a traumatic brain injury rat model
    Wee, Hsiao-Yue
    Lim, Sher-Wei
    Chio, Chung-Ching
    Niu, Ko-Chi
    Wang, Che-Chuan
    Kuo, Jinn-Rung
    JOURNAL OF SURGICAL RESEARCH, 2015, 197 (02) : 382 - 389
  • [8] Possible mechanisms of the PERK pathway on neuronal apoptosis in a rat model of surgical brain injury
    Wu, Mu-Yao
    Gao, Fan
    Tang, Jia-Feng
    Shen, Jin-Chao
    Gao, Rong
    Dang, Bao-Qi
    Chen, Gang
    AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2021, 13 (02): : 732 - 742
  • [9] Neuronal damage and functional deficits are ameliorated by inhibition of aquaporin and HIF1α after traumatic brain injury (TBI)
    Shenaq, Mohammed
    Kassem, Hassan
    Peng, Changya
    Schafer, Steven
    Ding, Jamie Y.
    Fredrickson, Vance
    Guthikonda, Murali
    Kreipke, Christian W.
    Rafols, Jose A.
    Ding, Yuchuan
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2012, 323 (1-2) : 134 - 140
  • [10] Edaravone attenuates neuronal apoptosis in hippocampus of rat traumatic brain injury model via activation of BDNF/TrkB signaling pathway
    Ding, Yuexia
    Zhu, Wei
    Kong, Wei
    Li, Tuo
    Zou, Peng
    Chen, Hongguang
    ARCHIVES OF MEDICAL SCIENCE, 2021, 17 (02) : 514 - 522
12345