Acute Kidney Injury in Neonates with Birth Asphyxia at a Tertiary Care Hospital

Objective: To determine acute kidney injury in perinatal asphyxia. Setting: The Neonatal Intensive Care Unit, Paediatrics Department, Combined Military Hospital, Hyderabad from 1st July 2020 to 31st December 2020. Methodology: One hundred and twenty neonates were included in the study. Lactate was sent within 30 min of birth in suspected birth asphyxia. Blood samples were collected from the neonates at 24 hours of life and sent for serum creatinine analysis to ascertain acute kidney injury in these children with perinatal asphyxia. Results: There were 56.7% male and 43.3% female neonates. Mean gestational age was 38.05 +/- 1.22 weeks. Mean APGAR score was 4.64 +/- 1.32. Mean serum lactate and serum creatinine was 5.15 +/- 0.63 mmol/L and 128.03 +/- 6.17 mu mol/L respectively. Fetal distress on cardiotocography was found in 47.5% cases while delayed cry was observed in 56.7% neonates. Most common grade of hypoxic ischemic encephalopathy was grade II in 57.55% neonates. 13.3% neonates were found to develop acute kidney injury. Conclusion: Significant frequency of acute kidney injury was also noted in our study in neonates having birth asphyxia. Gender of neonate and mode of delivery was found to be having significant association with acute kidney injury.