Pulmonary mucormycosis in the aftermath of critical COVID-19 in an immunocompromised patient: Mind the diagnostic gap

被引:7
|
作者
Crone, Cornelia Geisler [1 ]
Helweg-Larsen, Jannik [2 ]
Steensen, Morten [3 ]
Arendrup, Maiken Cavling [4 ,5 ,6 ]
Helleberg, Marie [1 ,2 ]
机构
[1] Rigshosp, Ctr Excellence Hlth Immun & Infect CHIP, Blegdamsvej 9, DK-2100 Copenhagen, Denmark
[2] Rigshosp, Dept Infect Dis, DK-2100 Copenhagen, Denmark
[3] Rigshosp, Dept Dept Intens Care, DK-2100 Copenhagen, Denmark
[4] Statens Serum Inst, Unit Mycol, DK-2300 Copenhagen, Denmark
[5] Rigshosp, Dept Clin Microbiol, DK-2100 Copenhagen, Denmark
[6] Univ Copenhagen, Dept Clin Med, DK-2100 Copenhagen, Denmark
来源
JOURNAL DE MYCOLOGIE MEDICALE | 2022年 / 32卷 / 01期
关键词
COVID-19; Mucormycosis; Immunosuppression; SARS-COV-2; Rhizopus microsporum; Invasive fungal infection; GRP78;
D O I
10.1016/j.mycmed.2021.101228
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Mucormycosis has recently been recognized as a severe complication of COVID-19 with high fatality rates. We report a fatal case of COVID-19 associated mucormycosis (CAM) in a non-diabetic immunocompromised patient, who was first misdiagnosed and treated for COVID-19 associated aspergillosis (CAPA). The risk factors and initial clinical presentation of CAPA and CAM are similar, but CAM has a more aggressive course and CAPA and CAM are treated differently. Dedicated diagnostic workup is essential to ensure early treatment of CAM with surgical debridement and targeted antifungal therapy. (c) 2021 The Author(s). Published by Elsevier Masson SAS on behalf of SFMM. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
引用
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页数:5
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