Role of Intestinal Dysbiosis and Nutrition in Rheumatoid Arthritis

被引：25
|
作者：
Attur, Malavikalakshmi [1 ]
Scher, Jose U. [2 ]
Abramson, Steven B. [2 ]
Attur, Mukundan [2 ]
机构：
[1] Drexel Univ, Coll Med, Philadelphia, PA 19129 USA
[2] NYU Langone Hlth, NYU Grossman Sch Med, Dept Med, Div Rheumatol, New York, NY 10003 USA
来源：
CELLS | 2022年 / 11卷 / 15期
关键词：
arthritis; microbiome; dysbiosis; nutrition; CHAIN FATTY-ACIDS; FECAL MICROBIOTA TRANSPLANTATION; COLLAGEN-INDUCED ARTHRITIS; GUT MICROBIOTA; LACTOBACILLUS-CASEI; MEDITERRANEAN DIET; DISEASE-ACTIVITY; VEGETARIAN DIET; T-CELLS; RISK;
D O I：
10.3390/cells11152436
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Rheumatoid arthritis is a chronic systemic immune-mediated disease caused by genetic and environmental factors. It is often characterized by the generation of autoantibodies that lead to synovial inflammation and eventual multi-joint destruction. A growing number of studies have shown significant differences in the gut microbiota composition of rheumatoid arthritis (RA) patients compared to healthy controls. Environmental factors, and changes in diet and nutrition are thought to play a role in developing this dysbiosis. This review aims to summarize the current knowledge of intestinal dysbiosis, the role of nutritional factors, and its implications in the pathogenesis of rheumatoid arthritis and autoimmunity. The future direction focuses on developing microbiome manipulation therapeutics for RA disease management.
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页数：14
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