Pathogenesis of Posttraumatic Osteoarthritis of the Ankle

被引：35

作者：

Nwankwo, Eugene C., Jr. ^{[1
,2
]}

Labaran, Lawal A. ^{[3
]}

Athas, Vincent ^{[2
]}

Olson, Steve ^{[1
]}

Adams, Samuel B. ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Orthoped Surg, 4709 Creekstone Dr, Durham, NC 27703 USA

[2] Texas Tech Univ, Hlth Sci Ctr, Sch Med, 3601 4th St, Lubbock, TX 79430 USA

[3] Univ Illinois, Coll Med, 1200 Harrison St, Chicago, IL 60607 USA

来源：

ORTHOPEDIC CLINICS OF NORTH AMERICA | 2019年 / 50卷 / 04期

关键词：

Ankle; Arthritis; Posttraumatic; Osteoarthritis; Pilon; Fracture; CHONDROGENIC PROGENITOR CELLS; DEGENERATIVE ARTHRITIS; INFLAMMATORY CYTOKINES; ARTICULAR-CARTILAGE; HUMAN KNEE; EPIDEMIOLOGY; DEGRADATION; FRACTURES; REPAIR;

D O I：

10.1016/j.ocl.2019.05.008

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Ankle osteoarthritis affects a significant portion of the global adult population. Unlike other joints, arthritis of the ankle often develops as a response to traumatic injury (intra-articular fracture) of the ankle joints. The full mechanism leading to posttraumatic osteoarthritis of the ankle (PTOAA) is poorly understood. These deficits in knowledge pose challenges in the management of the disease. Adequate surgical reduction of fractured ankle joints remains the gold standard in preventing. The purpose of this review is to thoroughly delineate the known pathogenesis of PTOAA, and provide critical updates on this pathology and new avenues to provide therapeutic management of the disease.

引用

页码：529 / +

页数：10

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