Vaccination using epitopes with higher MHC class I affinity elicits CD8+T cells with increased PD-1 expression

被引：0
|
作者：
Zahm, Christopher D. [1 ]
McNeel, Douglas [1 ]
机构：
[1] Univ Wisconsin, Madison, WI USA
来源：
CANCER RESEARCH | 2015年 / 75卷
关键词：
D O I：
10.1158/1538-7445.AM2015-2501
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
2501
引用
收藏
页数：1
相关论文
共 50 条
  • [1] Vaccination with High-Affinity Epitopes Impairs Antitumor Efficacy by Increasing PD-1 Expression on CD8+ T Cells
    Zahm, Christopher D.
    Colluru, Viswa T.
    McNeel, Douglas G.
    CANCER IMMUNOLOGY RESEARCH, 2017, 5 (08) : 630 - 641
  • [2] Blockade of PD-1 and LAG-3 expression on CD8+T cells promotes the tumoricidal effects of CD8+T cells
    Ma, Jiajia
    Yan, Shufang
    Zhao, Ying
    Yan, Huifang
    Zhang, Qian
    Li, Xinxia
    FRONTIERS IN IMMUNOLOGY, 2023, 14
  • [3] Increased PD-1 expression on CD4+and CD8+T cells is involved in immune evasion in gastric cancer
    Saito, Hiroaki
    Kuroda, Hirohiko
    Matsunaga, Tomoyuki
    Osaki, Tomohiro
    Ikeguchi, Masahide
    JOURNAL OF SURGICAL ONCOLOGY, 2013, 107 (05) : 517 - 522
  • [4] Blockade of PD-1 and LAG-3 on CD8+T cells, induced by vaccination, elicits superior anti-tumor efficacy
    Zahm, Christopher
    McNeel, Douglas
    Delmastro, Laurne
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7
  • [5] Higher PD-1 expression concurrent with exhausted CD8+T cells in patients with de novo acute myeloid leukemia
    Tan, Jiaxiong
    Chen, Shaohua
    Lu, Yuhong
    Yao, Danlin
    Xu, Ling
    Zhang, Yikai
    Yang, Lijian
    Chen, Jie
    Lai, Jing
    Yu, Zhi
    Zhu, Kanger
    Li, Yangqiu
    CHINESE JOURNAL OF CANCER RESEARCH, 2017, 29 (05) : 463 - 470
  • [6] Tracking Antigen-Specific CD8+T cells Using MHC Class I Pentamers
    Aleksandrovic, Emilija
    Lazarski, Christopher
    Bollard, Catherine
    Stanojevic, Maja
    Hanley, Patrick
    FASEB JOURNAL, 2020, 34
  • [7] Expansion of MHC class Ib restricted CD8+T cells in the absence of MHC class Ia and MHC class II expression
    Reed-Loisel, Lisa M.
    Jay, David C.
    Jensen, Peter E.
    JOURNAL OF IMMUNOLOGY, 2006, 176 : S292 - S293
  • [8] Low NK cell abundance correlates with high expression of PD-1 in CD8+T cells
    Lee, M. H.
    Jarvinen, P.
    Nisen, H.
    Bruck, O.
    Ilander, M.
    Mustjoki, S.
    Kreutzman, A.
    ANNALS OF ONCOLOGY, 2019, 30
  • [9] CD8+T Cells Activated Using a Low Affinity MHC Class I Ligand From Tyrosinase Related Protein 1 Lead to Tumor Rejection
    Povelko, Kevin D.
    Hansen, Michael J.
    Pease, Larry R.
    JOURNAL OF IMMUNOTHERAPY, 2008, 31 (09) : 947 - 947
  • [10] MGAT1 knockout in MUTZ-3 dendritic cells lead to increased expression of MHC class I/II and increased CD8+T cell activation
    Skovbakke, Sarah Line
    Blomberg, Anne Louise
    Tian, Weihua
    Goletz, Steffen
    GLYCOBIOLOGY, 2023, 33 (11) : 1009 - 1009
12345