miR-22-3p/PGC1β Suppresses Breast Cancer Cell Tumorigenesis via PPARγ

被引：19
|
作者：
Wang, Xuehui [1 ,2 ]
Yao, Zhilu [1 ,2 ]
Fang, Lin [1 ,2 ]
机构：
[1] Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Thyroid & Breast Surg, Shanghai 200072, Peoples R China
[2] Nanjing Med Univ, Nanjing 211166, Peoples R China
来源：
PPAR RESEARCH | 2021年 / 2021卷
基金：
中国国家自然科学基金;
关键词：
INHIBITS PROLIFERATION; PGC-1-BETA; METASTASIS; APOPTOSIS;
D O I：
10.1155/2021/6661828
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
In this study, we found that miR-22-3p expression was decreased in breast cancer (BC) cell lines and tissues. Overexpression of miR-22-3p inhibited the proliferation and migration of BC cells in vitro and in vivo, while depletion of miR-22-3p exhibited the opposite effect. Importantly, miR-22-3p could directly target PGC1 beta and finally regulate the PPAR gamma pathway in BC. In conclusion, miR-22-3p/PGC1 beta suppresses BC cell tumorigenesis via PPAR gamma, which may become a potential biomarker and therapeutic target.
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收藏
页数：15
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